Imaging and speciation of intracellular metallic implant debris using synchrotron-based X-ray fluorescence micro-spectroscopy: a study of two cases

Imaging and speciation of intracellular metallic implant debris using synchrotron-based X-ray fluorescence micro-spectroscopy: a study of two cases

Abstract Debris generated from total hip arthroplasty (THA) components made from metal alloys can cause, in some cases, inflammatory cell (e.g., macrophages) responses that lead to adverse local tissue reactions (ALTR) and implant failure. The lack of information on intracellular chemical alteration...

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Bibliographic Details
Main Authors: Songyun Liu, Si Chen, Barry Lai, Olga Antipova, Yanqi Luo, Deborah J. Hall, Qiaoling Jin, Evan Maxey, Joshua J. Jacobs, Robin Pourzal
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-94231-7
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