Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil
Patchouli oil (PO), extracted from Pogostemon cablin Benth., a prominent aromatic plant of the Lamiaceae family, has shown considerable protective effects against gastrointestinal infections, particularly those induced by Helicobacter pylori. This study aimed to develop a gastro-floating multi-unit...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024164055 |
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| author | Chen Liu Yanan Wu Yeli Zou Jiao Wang Boli Li Yanni Ma Xia Zhang Wenping Wang |
| author_facet | Chen Liu Yanan Wu Yeli Zou Jiao Wang Boli Li Yanni Ma Xia Zhang Wenping Wang |
| author_sort | Chen Liu |
| collection | DOAJ |
| description | Patchouli oil (PO), extracted from Pogostemon cablin Benth., a prominent aromatic plant of the Lamiaceae family, has shown considerable protective effects against gastrointestinal infections, particularly those induced by Helicobacter pylori. This study aimed to develop a gastro-floating multi-unit system for PO to enhance its gastric retention and oral bioavailability. Methods: The oil-laden granules were prepared using colloidal silicon dioxide (CSD) for oil adsorption and to provide buoyancy, along with ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) to form a sustained-release matrix. The CSD exhibited favorable characteristics for oil adsorption and floating. Compatibility between PO and CSD was affirmed through DSC thermograms and FTIR spectra. The obtained granules demonstrated a sustained release profile, achieving over 90 % release within 10 h without an initial burst. After oral administration, the granules were observed to remain in the gastric region of rats for over 7 h. The bioavailability of patchouli alcohol from the optimized granules was significantly higher than that from of the PO-loaded powders. The gastro-floating sustained-release granules, based on a CSD/EC/HPMC matrix, offer a simple yet effective strategy to improve the delivery efficacy of PO against Helicobacter pylori infections in the gastric region. |
| format | Article |
| id | doaj-art-bbd0ac40ec404210b0fba7af9d3713d0 |
| institution | DOAJ |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-bbd0ac40ec404210b0fba7af9d3713d02025-08-20T02:49:53ZengElsevierHeliyon2405-84402024-12-011023e4037410.1016/j.heliyon.2024.e40374Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oilChen Liu0Yanan Wu1Yeli Zou2Jiao Wang3Boli Li4Yanni Ma5Xia Zhang6Wenping Wang7General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China; College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan, 750004, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan, 750004, ChinaCollege of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan, 750004, ChinaGeneral Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan, 750004, ChinaCollege of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, China; Corresponding author.Patchouli oil (PO), extracted from Pogostemon cablin Benth., a prominent aromatic plant of the Lamiaceae family, has shown considerable protective effects against gastrointestinal infections, particularly those induced by Helicobacter pylori. This study aimed to develop a gastro-floating multi-unit system for PO to enhance its gastric retention and oral bioavailability. Methods: The oil-laden granules were prepared using colloidal silicon dioxide (CSD) for oil adsorption and to provide buoyancy, along with ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) to form a sustained-release matrix. The CSD exhibited favorable characteristics for oil adsorption and floating. Compatibility between PO and CSD was affirmed through DSC thermograms and FTIR spectra. The obtained granules demonstrated a sustained release profile, achieving over 90 % release within 10 h without an initial burst. After oral administration, the granules were observed to remain in the gastric region of rats for over 7 h. The bioavailability of patchouli alcohol from the optimized granules was significantly higher than that from of the PO-loaded powders. The gastro-floating sustained-release granules, based on a CSD/EC/HPMC matrix, offer a simple yet effective strategy to improve the delivery efficacy of PO against Helicobacter pylori infections in the gastric region.http://www.sciencedirect.com/science/article/pii/S2405844024164055Patchouli oilGastroretentive granulesBioavailabilitySustained releaseColloidal silicon dioxideAdsorption |
| spellingShingle | Chen Liu Yanan Wu Yeli Zou Jiao Wang Boli Li Yanni Ma Xia Zhang Wenping Wang Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil Heliyon Patchouli oil Gastroretentive granules Bioavailability Sustained release Colloidal silicon dioxide Adsorption |
| title | Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil |
| title_full | Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil |
| title_fullStr | Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil |
| title_full_unstemmed | Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil |
| title_short | Development and characterization of gastro-floating sustained-release granules for enhanced bioavailability of patchouli oil |
| title_sort | development and characterization of gastro floating sustained release granules for enhanced bioavailability of patchouli oil |
| topic | Patchouli oil Gastroretentive granules Bioavailability Sustained release Colloidal silicon dioxide Adsorption |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024164055 |
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