Efficacy of paleolithic diet in control of blood glucose level in type 2 DM patients
Abstract Background Type 2 Diabetes Mellitus (T2DM) is a widespread metabolic disorder characterized by poor regulation of blood glucose and resistance to insulin. Dietary strategies play a crucial role in the management of T2DM, and the Paleolithic Diet (PD), which emphasizes whole, unprocessed foo...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-08-01
|
| Series: | The Egyptian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43162-025-00453-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract Background Type 2 Diabetes Mellitus (T2DM) is a widespread metabolic disorder characterized by poor regulation of blood glucose and resistance to insulin. Dietary strategies play a crucial role in the management of T2DM, and the Paleolithic Diet (PD), which emphasizes whole, unprocessed foods, has demonstrated potential in enhancing glycemic control and overall metabolic function. However, its comparative efficacy against standard treatments remains a subject of ongoing debate. Aim This study aimed to evaluate the effect of the Paleolithic Diet (PD) on glycemic control as the primary outcome and its impact on insulin sensitivity and lipid profiles as secondary outcomes in patients with T2DM. Methods A total of 100 individuals diagnosed with T2DM were recruited and allocated into two groups: the intervention group (n = 50), which followed the PD alongside standard therapy, and the control group (n = 50), which received standard therapy alone. Evaluations were conducted at baseline and three months post-intervention, focusing on glycemic parameters (fasting glucose, HbA1c, HOMA-IR), lipid markers (cholesterol, triglycerides, LDL), and anthropometric data (BMI, waist circumference). Results At baseline, both groups were comparable in demographic characteristics, diabetes duration, and laboratory measurements. After three months, the intervention group exhibited significantly better glycemic outcomes, including lower fasting glucose levels (152.45 ± 22.67 vs. 189.11 ± 21.98 mg/dl, 95% CI: -8.99, + 13.21 p = 0.001), HbA1c values (6.23 ± 1.98 vs. 8.90 ± 2.11%,95% CI: -3.42,-2.42 p = 0.03), and HOMA-IR scores (1.64 ± 0.50 vs. 2.38 ± 0.37, 95% CI: -1.43,-0.97 p < 0.001). Additionally, participants in the PD group showed marked improvements in lipid profiles, with reductions in cholesterol (149.18 ± 29.09 vs. 201.26 ± 20.11 mg/dl, 95% CI: -98.21,-71.45 p < 0.001), triglycerides (111.54 ± 18.67 vs. 136.44 ± 34.90 mg/dl, 95% CI: -45.21,-21.98 p = 0.01), and LDL (109.10 ± 21.50 vs. 134.33 ± 12.37 mg/dl, 95% CI: -30.54,-11.48 p = 0.01). No notable changes in BMI or waist circumference were observed in either group. Conclusion This study suggests that the Paleolithic Diet (PD) may lead to improvements in glycemic control, insulin sensitivity, and lipid profiles in patients with T2DM over a three-month period. Participants following the PD showed lower fasting blood glucose, HbA1c, and HOMA-IR scores compared to the control group, as well as improvements in cholesterol and triglyceride levels. |
|---|---|
| ISSN: | 2090-9098 |