Exploring the bioactive landscape: peptides and non-peptides from the human microbiota

Abstract The human microbiota, consisting of trillions of bacteria from six main phyla, produces peptide and non-peptide secondary metabolites which have antibacterial properties vital to medicine and biotechnology. These metabolites influence biological processes linked to diseases, yet much remain...

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Bibliographic Details
Main Authors: Abdul Bari Shah, Hyeonjae Cho, Sang Hee Shim
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-025-00713-x
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Summary:Abstract The human microbiota, consisting of trillions of bacteria from six main phyla, produces peptide and non-peptide secondary metabolites which have antibacterial properties vital to medicine and biotechnology. These metabolites influence biological processes linked to diseases, yet much remains unknown. This review explores their structures and functions, aiming to spur novel metabolite discovery and advance drug development.
ISSN:2055-5008