Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India.
The decline in dengue incidence and/or prevalence during the COVID-19 pandemic (2020-22) appears to be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted health services and reduced exposure to mosquito vectors due to prevailing lockdowns. There is limited scient...
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://doi.org/10.1371/journal.pgph.0003608 |
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| author | Sivaprakasam T Selvavinayagam Sathish Sankar Yean K Yong Abdul R Anshad Samudi Chandramathi Anavarathan Somasundaram Sampath Palani Parthipan Kumarasamy Roshini Azhaguvel Ajith B Kumar Sudharshini Subramaniam Manickam Malathi Venkatachalam Vijayalakshmi Manivannan Rajeshkumar Anandhazhvar Kumaresan Ramendra P Pandey Nagarajan Muruganandam Natarajan Gopalan Meganathan Kannan Amudhan Murugesan Pachamuthu Balakrishnan Siddappa N Byrareddy Aditya P Dash Vijayakumar Velu Marie Larsson Esaki M Shankar Sivadoss Raju |
| author_facet | Sivaprakasam T Selvavinayagam Sathish Sankar Yean K Yong Abdul R Anshad Samudi Chandramathi Anavarathan Somasundaram Sampath Palani Parthipan Kumarasamy Roshini Azhaguvel Ajith B Kumar Sudharshini Subramaniam Manickam Malathi Venkatachalam Vijayalakshmi Manivannan Rajeshkumar Anandhazhvar Kumaresan Ramendra P Pandey Nagarajan Muruganandam Natarajan Gopalan Meganathan Kannan Amudhan Murugesan Pachamuthu Balakrishnan Siddappa N Byrareddy Aditya P Dash Vijayakumar Velu Marie Larsson Esaki M Shankar Sivadoss Raju |
| author_sort | Sivaprakasam T Selvavinayagam |
| collection | DOAJ |
| description | The decline in dengue incidence and/or prevalence during the COVID-19 pandemic (2020-22) appears to be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted health services and reduced exposure to mosquito vectors due to prevailing lockdowns. There is limited scientific data on dengue virus (DENV) disease during the COVID-19 pandemic. Here, we conducted a community-based, cross-sectional, cluster-randomized survey to assess anti-DENV and anti-SARS-CoV-2 seroprevalence, and also estimated the spatial distribution of DENV-positive aedine mosquito vectors during the COVID-19 pandemic across all the 38 districts of Tamil Nadu, India. Using real-time PCR, the prevalence of DENV in mosquito pools during 2021 was analyzed and compared with the previous and following years of vector surveillance, and correlated with anti-DENV IgM and IgG levels in the population. Results implicate that both anti-DENV IgM and IgG seroprevalence and DENV positivity in mosquito pools were reduced across all the districts. A total of 13464 mosquito pools and 5577 human serum samples from 186 clusters were collected. Of these, 3.76% of the mosquito pools were positive for DENV. In the human sera, 4.12% were positive for anti-DENV IgM and 6.4% for anti-DENV IgG. While the anti-SARS-CoV-2 levels significantly correlated with overall DENV seropositivity, COVID-19 vaccination status significantly correlated with anti-DENV IgM levels. The study indicates a profound impact of anti-SARS-CoV-2 levels on DENV-positive mosquito pools and seropositivity. Continuous monitoring of anti-DENV antibody levels, especially with the evolving variants of SARS-CoV-2 and the surge in COVID-19 cases will shed light on the distribution, transmission and therapeutic attributes of DENV infection. |
| format | Article |
| id | doaj-art-bbc751b3750845b19a98d46971971fc0 |
| institution | Kabale University |
| issn | 2767-3375 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj-art-bbc751b3750845b19a98d46971971fc02025-01-08T05:51:37ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752024-01-01411e000360810.1371/journal.pgph.0003608Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India.Sivaprakasam T SelvavinayagamSathish SankarYean K YongAbdul R AnshadSamudi ChandramathiAnavarathan SomasundaramSampath PalaniParthipan KumarasamyRoshini AzhaguvelAjith B KumarSudharshini SubramaniamManickam MalathiVenkatachalam VijayalakshmiManivannan RajeshkumarAnandhazhvar KumaresanRamendra P PandeyNagarajan MuruganandamNatarajan GopalanMeganathan KannanAmudhan MurugesanPachamuthu BalakrishnanSiddappa N ByrareddyAditya P DashVijayakumar VeluMarie LarssonEsaki M ShankarSivadoss RajuThe decline in dengue incidence and/or prevalence during the COVID-19 pandemic (2020-22) appears to be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted health services and reduced exposure to mosquito vectors due to prevailing lockdowns. There is limited scientific data on dengue virus (DENV) disease during the COVID-19 pandemic. Here, we conducted a community-based, cross-sectional, cluster-randomized survey to assess anti-DENV and anti-SARS-CoV-2 seroprevalence, and also estimated the spatial distribution of DENV-positive aedine mosquito vectors during the COVID-19 pandemic across all the 38 districts of Tamil Nadu, India. Using real-time PCR, the prevalence of DENV in mosquito pools during 2021 was analyzed and compared with the previous and following years of vector surveillance, and correlated with anti-DENV IgM and IgG levels in the population. Results implicate that both anti-DENV IgM and IgG seroprevalence and DENV positivity in mosquito pools were reduced across all the districts. A total of 13464 mosquito pools and 5577 human serum samples from 186 clusters were collected. Of these, 3.76% of the mosquito pools were positive for DENV. In the human sera, 4.12% were positive for anti-DENV IgM and 6.4% for anti-DENV IgG. While the anti-SARS-CoV-2 levels significantly correlated with overall DENV seropositivity, COVID-19 vaccination status significantly correlated with anti-DENV IgM levels. The study indicates a profound impact of anti-SARS-CoV-2 levels on DENV-positive mosquito pools and seropositivity. Continuous monitoring of anti-DENV antibody levels, especially with the evolving variants of SARS-CoV-2 and the surge in COVID-19 cases will shed light on the distribution, transmission and therapeutic attributes of DENV infection.https://doi.org/10.1371/journal.pgph.0003608 |
| spellingShingle | Sivaprakasam T Selvavinayagam Sathish Sankar Yean K Yong Abdul R Anshad Samudi Chandramathi Anavarathan Somasundaram Sampath Palani Parthipan Kumarasamy Roshini Azhaguvel Ajith B Kumar Sudharshini Subramaniam Manickam Malathi Venkatachalam Vijayalakshmi Manivannan Rajeshkumar Anandhazhvar Kumaresan Ramendra P Pandey Nagarajan Muruganandam Natarajan Gopalan Meganathan Kannan Amudhan Murugesan Pachamuthu Balakrishnan Siddappa N Byrareddy Aditya P Dash Vijayakumar Velu Marie Larsson Esaki M Shankar Sivadoss Raju Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India. PLOS Global Public Health |
| title | Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India. |
| title_full | Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India. |
| title_fullStr | Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India. |
| title_full_unstemmed | Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India. |
| title_short | Attrition in serum anti-DENV antibodies correlates with high anti-SARS-CoV-2 IgG levels and low DENV positivity in mosquito vectors-Findings from a state-wide cluster-randomized community-based study in Tamil Nadu, India. |
| title_sort | attrition in serum anti denv antibodies correlates with high anti sars cov 2 igg levels and low denv positivity in mosquito vectors findings from a state wide cluster randomized community based study in tamil nadu india |
| url | https://doi.org/10.1371/journal.pgph.0003608 |
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