The role of MLH1, MSH2 and MSH6 in the development of colorectal cancer in Uganda

The role of MLH1, MSH2 and MSH6 in the development of colorectal cancer in Uganda

Abstract Introduction In Uganda, colorectal cancer (CRC) is steadily increasing according to the Kampala Cancer Registry. In the West, microsatellite instability is detected in 90% of hereditary nonpolyposis colon cancers (HNPCC) which account for 1–2% of all CRC, and 15% of sporadic CRC. Germline m...

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Bibliographic Details
Main Authors: Richard Wismayer, Rosie Matthews, Celina Whalley, Julius Kiwanuka, Fredrick Elishama Kakembo, Steve Thorn, Henry Wabinga, Michael Odida, Ian Tomlinson
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Microsatellite instability (MSI)
Microsatellite stable (MSS)
Immunohistochemistry
Uganda
Online Access:https://doi.org/10.1186/s12885-025-14195-9
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