Correlation between invasive and noninvasive oxygen indices in critically ill COVID patients with ARDS: A retrospective analysis
Objective: This study aims to evaluate the correlation between peripheral oxygen saturation/fraction of inspired oxygen (SpO2/FiO2) and arterial partial pressure of oxygen (PaO2)/FiO2 ratio in the diagnosis and assessment of severity in acute respiratory distress syndrome (ARDS) patients admitted to...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | The Journal of Association of Chest Physicians |
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| Online Access: | https://journals.lww.com/10.4103/jacp.jacp_23_24 |
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| author | Arin Choudhury Meena Singh Amandeep Jaswal Saurav Mitra Mustafi Santvana Kohli |
| author_facet | Arin Choudhury Meena Singh Amandeep Jaswal Saurav Mitra Mustafi Santvana Kohli |
| author_sort | Arin Choudhury |
| collection | DOAJ |
| description | Objective: This study aims to evaluate the correlation between peripheral oxygen saturation/fraction of inspired oxygen (SpO2/FiO2) and arterial partial pressure of oxygen (PaO2)/FiO2 ratio in the diagnosis and assessment of severity in acute respiratory distress syndrome (ARDS) patients admitted to intensive care unit (ICU) during the SARS-CoV-2 outbreak. Methods: A retrospective observational study was conducted in patients admitted to COVID-ICU during a 1-year period. Time coinciding values of SpO2 and PaO2 were noted from patients’ medical records. An evaluation was made to judge the efficacy of the SpO2/FiO2 ratio (S/F ratio) for the prediction of 100, 200, 300, and >300 mmHg cutoff values of PaO2/FiO2 ratio (P/F ratio) using receiver operating characteristic (ROC) curves. Results: The medical records of 196 patients were evaluated. A strong positive correlation was identified between P/F and S/F ratios in the sample population (correlation coefficient r = 0.716, p < 0.002). The area under the ROC curve of the S/F ratio was 0.720 (95% confidence interval [CI] 0.637–0.804) for mild ARDS. The optimal S/F threshold was found to be ≤411% (sensitivity and specificity 65% and 80%, respectively). Similarly, the S/F threshold was ≤405% (area under the curve [AUC] 0.781, 95% CI 0.713–0.848, p < 0.000) for moderate ARDS (sensitivity 71.8% and specificity 70.8%), and ≤ 395% (AUC 0.762, 95% CI 0.689–0.835, p < 0.000) for severe ARDS (specificity 73.5% and sensitivity 66.7%). Conclusions: The S/F ratio can be used as a reliable, noninvasive alternative tool for the diagnosis of ARDS and assessment of severity. This can be used as an early warning score in patients admitted in low-resource settings with respiratory illness, and an escalation of care can be decided. |
| format | Article |
| id | doaj-art-bbc4aa2dab0f4b4d978804830e6d987f |
| institution | Kabale University |
| issn | 2320-8775 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Journal of Association of Chest Physicians |
| spelling | doaj-art-bbc4aa2dab0f4b4d978804830e6d987f2025-01-04T10:30:50ZengWolters Kluwer Medknow PublicationsThe Journal of Association of Chest Physicians2320-87752024-12-0112416016610.4103/jacp.jacp_23_24Correlation between invasive and noninvasive oxygen indices in critically ill COVID patients with ARDS: A retrospective analysisArin ChoudhuryMeena SinghAmandeep JaswalSaurav Mitra MustafiSantvana KohliObjective: This study aims to evaluate the correlation between peripheral oxygen saturation/fraction of inspired oxygen (SpO2/FiO2) and arterial partial pressure of oxygen (PaO2)/FiO2 ratio in the diagnosis and assessment of severity in acute respiratory distress syndrome (ARDS) patients admitted to intensive care unit (ICU) during the SARS-CoV-2 outbreak. Methods: A retrospective observational study was conducted in patients admitted to COVID-ICU during a 1-year period. Time coinciding values of SpO2 and PaO2 were noted from patients’ medical records. An evaluation was made to judge the efficacy of the SpO2/FiO2 ratio (S/F ratio) for the prediction of 100, 200, 300, and >300 mmHg cutoff values of PaO2/FiO2 ratio (P/F ratio) using receiver operating characteristic (ROC) curves. Results: The medical records of 196 patients were evaluated. A strong positive correlation was identified between P/F and S/F ratios in the sample population (correlation coefficient r = 0.716, p < 0.002). The area under the ROC curve of the S/F ratio was 0.720 (95% confidence interval [CI] 0.637–0.804) for mild ARDS. The optimal S/F threshold was found to be ≤411% (sensitivity and specificity 65% and 80%, respectively). Similarly, the S/F threshold was ≤405% (area under the curve [AUC] 0.781, 95% CI 0.713–0.848, p < 0.000) for moderate ARDS (sensitivity 71.8% and specificity 70.8%), and ≤ 395% (AUC 0.762, 95% CI 0.689–0.835, p < 0.000) for severe ARDS (specificity 73.5% and sensitivity 66.7%). Conclusions: The S/F ratio can be used as a reliable, noninvasive alternative tool for the diagnosis of ARDS and assessment of severity. This can be used as an early warning score in patients admitted in low-resource settings with respiratory illness, and an escalation of care can be decided.https://journals.lww.com/10.4103/jacp.jacp_23_24ardscovidicuoxygen indicesp/f ratiosars-cov-2s/f ratio |
| spellingShingle | Arin Choudhury Meena Singh Amandeep Jaswal Saurav Mitra Mustafi Santvana Kohli Correlation between invasive and noninvasive oxygen indices in critically ill COVID patients with ARDS: A retrospective analysis The Journal of Association of Chest Physicians ards covid icu oxygen indices p/f ratio sars-cov-2 s/f ratio |
| title | Correlation between invasive and noninvasive oxygen indices in critically ill COVID patients with ARDS: A retrospective analysis |
| title_full | Correlation between invasive and noninvasive oxygen indices in critically ill COVID patients with ARDS: A retrospective analysis |
| title_fullStr | Correlation between invasive and noninvasive oxygen indices in critically ill COVID patients with ARDS: A retrospective analysis |
| title_full_unstemmed | Correlation between invasive and noninvasive oxygen indices in critically ill COVID patients with ARDS: A retrospective analysis |
| title_short | Correlation between invasive and noninvasive oxygen indices in critically ill COVID patients with ARDS: A retrospective analysis |
| title_sort | correlation between invasive and noninvasive oxygen indices in critically ill covid patients with ards a retrospective analysis |
| topic | ards covid icu oxygen indices p/f ratio sars-cov-2 s/f ratio |
| url | https://journals.lww.com/10.4103/jacp.jacp_23_24 |
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