Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation
Stroke is a common, debilitating trauma that has an incompletely elucidated pathophysiology and lacks an effective therapy. FoxP3+CD25+CD4+ regulatory T cells (Tregs) suppress a variety of normal physiological and pathological immune responses via several pathways, such as inhibitory cytokine secret...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/689827 |
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| author | Sheng Chen Haijian Wu Damon Klebe Yuan Hong Jianmin Zhang Jiping Tang |
| author_facet | Sheng Chen Haijian Wu Damon Klebe Yuan Hong Jianmin Zhang Jiping Tang |
| author_sort | Sheng Chen |
| collection | DOAJ |
| description | Stroke is a common, debilitating trauma that has an incompletely elucidated pathophysiology and lacks an effective therapy. FoxP3+CD25+CD4+ regulatory T cells (Tregs) suppress a variety of normal physiological and pathological immune responses via several pathways, such as inhibitory cytokine secretion, direct cytolysis induction, and antigen-presenting cell functional modulation. FoxP3+CD25+CD4+ Tregs are involved in a variety of central nervous system diseases and injuries, including axonal injury, neurodegenerative diseases, and stroke. Specifically, FoxP3+CD25+CD4+ Tregs exert neuroprotective effects in acute experimental stroke models. These beneficial effects, however, are difficult to elucidate. In this review, we summarized evidence of FoxP3+CD25+CD4+ Tregs as potentially important immunomodulators in stroke pathogenesis and highlight further investigations for possible immunotherapeutic strategies by modulating the quantity and/or functional effects of FoxP3+CD25+CD4+ Tregs in stroke patients. |
| format | Article |
| id | doaj-art-bbc3bc7ec0f445d1956d533cbc3603ec |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-bbc3bc7ec0f445d1956d533cbc3603ec2025-08-20T02:18:42ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/689827689827Regulatory T Cell in Stroke: A New Paradigm for Immune RegulationSheng Chen0Haijian Wu1Damon Klebe2Yuan Hong3Jianmin Zhang4Jiping Tang5Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, ChinaDepartment of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USADepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, ChinaDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, ChinaDepartment of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA 92350, USAStroke is a common, debilitating trauma that has an incompletely elucidated pathophysiology and lacks an effective therapy. FoxP3+CD25+CD4+ regulatory T cells (Tregs) suppress a variety of normal physiological and pathological immune responses via several pathways, such as inhibitory cytokine secretion, direct cytolysis induction, and antigen-presenting cell functional modulation. FoxP3+CD25+CD4+ Tregs are involved in a variety of central nervous system diseases and injuries, including axonal injury, neurodegenerative diseases, and stroke. Specifically, FoxP3+CD25+CD4+ Tregs exert neuroprotective effects in acute experimental stroke models. These beneficial effects, however, are difficult to elucidate. In this review, we summarized evidence of FoxP3+CD25+CD4+ Tregs as potentially important immunomodulators in stroke pathogenesis and highlight further investigations for possible immunotherapeutic strategies by modulating the quantity and/or functional effects of FoxP3+CD25+CD4+ Tregs in stroke patients.http://dx.doi.org/10.1155/2013/689827 |
| spellingShingle | Sheng Chen Haijian Wu Damon Klebe Yuan Hong Jianmin Zhang Jiping Tang Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation Clinical and Developmental Immunology |
| title | Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation |
| title_full | Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation |
| title_fullStr | Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation |
| title_full_unstemmed | Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation |
| title_short | Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation |
| title_sort | regulatory t cell in stroke a new paradigm for immune regulation |
| url | http://dx.doi.org/10.1155/2013/689827 |
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