A Candidate Ac<sub>3</sub>-S-LPS Vaccine Against <i>S. flexneri</i> 1b, 2a, 3a, 6, and Y Activates Long-Lived Systemic and Mucosal Immune Responses in Healthy Volunteers: Results of an Open-Label, Randomized 2 Clinical Trial

A Candidate Ac<sub>3</sub>-S-LPS Vaccine Against <i>S. flexneri</i> 1b, 2a, 3a, 6, and Y Activates Long-Lived Systemic and Mucosal Immune Responses in Healthy Volunteers: Results of an Open-Label, Randomized 2 Clinical Trial

Objectives: Determination of reactogenicity and immunogenicity of a pentavalent candidate vaccine against <i>S. flexneri</i> 1b, 2a, 3a, 6, and Y (PLVF). Methods: The study involved 80 healthy adult volunteers aged 18–55 years. Groups were subcutaneously immunized twice at a 30-day inter...

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Bibliographic Details
Main Authors: Vladimir A. Ledov, Victor V. Romanenko, Marina E. Golovina, Biana I. Alkhazova, Alexander L. Kovalchuk, Petr G. Aparin
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Vaccines
Subjects:
<i>Shigella flexneri</i>
vaccine
lipopolysaccharide
Online Access:https://www.mdpi.com/2076-393X/13/3/209
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