Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind study
Background and Aims: Intravenous magnesium sulfate is known to reduce hemodynamic response of laryngoscopy and intubation. However, it is associated with some systemic side effects. We compared the efficacy of nebulized and intravenous magnesium sulfate pretreatment on attenuation of hemodynamic res...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/joacp.joacp_484_24 |
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| author | Kajal Shrestha Priyanka Gupta Mridul Dhar |
| author_facet | Kajal Shrestha Priyanka Gupta Mridul Dhar |
| author_sort | Kajal Shrestha |
| collection | DOAJ |
| description | Background and Aims:
Intravenous magnesium sulfate is known to reduce hemodynamic response of laryngoscopy and intubation. However, it is associated with some systemic side effects. We compared the efficacy of nebulized and intravenous magnesium sulfate pretreatment on attenuation of hemodynamic response during tracheal intubation.
Material and Methods:
Sixty-six American Society of Anesthesiologists classification I–II patients aged 18–65 were randomly assigned to two groups: Group IV, which received 30 mg/kg of intravenous magnesium sulfate, and Group IN, which received the same dose via nebulization. Intubation was performed by an experienced anesthesiologist who was blinded to group allocation. The primary outcomes were heart rate (HR) and mean arterial pressure (MAP) during laryngoscopy and intubation. Secondary outcomes included propofol consumption for anesthesia induction, time to achieve a train-of-four (TOF) ratio of 0 after vecuronium administration, and any adverse effects.
Results:
Both groups showed similar attenuation of hemodynamic responses during laryngoscopy and intubation (HR: P =0.139, MAP: P =0.40). Propofol consumption (mg) was comparable between the groups (113.64 in Group IN vs. 113.79 in Group IV, P = 0.629). However, the time (seconds) to achieve a TOF ratio of 0 was significantly shorter in Group IV compared to Group IN (228.33 vs. 247.09, P = 0.035).
Conclusion:
Nebulized magnesium sulfate was as effective as intravenous magnesium sulfate in reducing hemodynamic changes during intubation, offering a noninvasive alternative for managing this response. |
| format | Article |
| id | doaj-art-bbbd1a7017d9474b8f497d1d3fcbe6b6 |
| institution | Kabale University |
| issn | 0970-9185 2231-2730 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj-art-bbbd1a7017d9474b8f497d1d3fcbe6b62025-08-20T03:31:33ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852231-27302025-07-0141353854210.4103/joacp.joacp_484_24Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind studyKajal ShresthaPriyanka GuptaMridul DharBackground and Aims: Intravenous magnesium sulfate is known to reduce hemodynamic response of laryngoscopy and intubation. However, it is associated with some systemic side effects. We compared the efficacy of nebulized and intravenous magnesium sulfate pretreatment on attenuation of hemodynamic response during tracheal intubation. Material and Methods: Sixty-six American Society of Anesthesiologists classification I–II patients aged 18–65 were randomly assigned to two groups: Group IV, which received 30 mg/kg of intravenous magnesium sulfate, and Group IN, which received the same dose via nebulization. Intubation was performed by an experienced anesthesiologist who was blinded to group allocation. The primary outcomes were heart rate (HR) and mean arterial pressure (MAP) during laryngoscopy and intubation. Secondary outcomes included propofol consumption for anesthesia induction, time to achieve a train-of-four (TOF) ratio of 0 after vecuronium administration, and any adverse effects. Results: Both groups showed similar attenuation of hemodynamic responses during laryngoscopy and intubation (HR: P =0.139, MAP: P =0.40). Propofol consumption (mg) was comparable between the groups (113.64 in Group IN vs. 113.79 in Group IV, P = 0.629). However, the time (seconds) to achieve a TOF ratio of 0 was significantly shorter in Group IV compared to Group IN (228.33 vs. 247.09, P = 0.035). Conclusion: Nebulized magnesium sulfate was as effective as intravenous magnesium sulfate in reducing hemodynamic changes during intubation, offering a noninvasive alternative for managing this response.https://journals.lww.com/10.4103/joacp.joacp_484_24intravenousintubationlaryngoscopymagnesium sulfatenebulization |
| spellingShingle | Kajal Shrestha Priyanka Gupta Mridul Dhar Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind study Journal of Anaesthesiology Clinical Pharmacology intravenous intubation laryngoscopy magnesium sulfate nebulization |
| title | Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind study |
| title_full | Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind study |
| title_fullStr | Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind study |
| title_full_unstemmed | Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind study |
| title_short | Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind study |
| title_sort | comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery a randomized double blind study |
| topic | intravenous intubation laryngoscopy magnesium sulfate nebulization |
| url | https://journals.lww.com/10.4103/joacp.joacp_484_24 |
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