Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes

Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes

Abstract Elevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their genetic and phenotypic similarities and identify seven clu...

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Main Authors: Magdalena Sevilla-González, Kirk Smith, Ningyuan Wang, Aubrey E. Jensen, Elizabeth M. Litkowski, Hyunkyung Kim, Daniel A. DiCorpo, Sarah Hsu, Jinrui Cui, Ching-Ti Liu, Chenglong Yu, John J. McNeil, Paul Lacaze, Kenneth E. Westerman, Kyong-Mi Chang, Philip S. Tsao, Lawrence S. Phillips, Mark O. Goodarzi, Rob Sladek, Jerome I. Rotter, Josée Dupuis, Jose C. Florez, Jordi Merino, James B. Meigs, Jin J. Zhou, Sridharan Raghavan, Miriam S. Udler, Alisa K. Manning
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57452-y
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