Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease
Ferroptosis is a special type of programmed cell death, which is different from autophagy, apoptosis and other modes of death, and characterized by mitochondrial shrinkage, membrane density increase and ridge reduction. The mechanism of ferroptosis is mainly related to the dysregulation of intracell...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Guangxi Medical University
2024-08-01
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| Series: | Guangxi Yike Daxue xuebao |
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| Online Access: | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.08.015 |
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| author | CAI Xiaoyu GAO Feng HUANG Bin QIN Huiping |
| author_facet | CAI Xiaoyu GAO Feng HUANG Bin QIN Huiping |
| author_sort | CAI Xiaoyu |
| collection | DOAJ |
| description | Ferroptosis is a special type of programmed cell death, which is different from autophagy, apoptosis and other modes of death, and characterized by mitochondrial shrinkage, membrane density increase and ridge reduction. The mechanism of ferroptosis is mainly related to the dysregulation of intracellular iron metabolism system, lipid peroxidation, and reduction of glutathione. Chronic obstructive pulmonary disease (COPD) has developed into a serious chronic respiratory disease threatening human health. Chronic inflammation, oxidative stress, and protease/antiprotease imbalance caused by inhalation of tobacco or other atmospheric particles contribute to the development of COPD. Epigenetic modifications affect the heritable expression of genes through histone or nucleic acid sequence modification, and regulate the expression of genes in the ferroptosis-related pathway to amplify or inhibit the role of ferroptosis in COPD. These modifications provide potential therapeutic targets for the disease progression. In this paper, the mechanism of ferroptosis, the relationship between ferroptosis and COPD, and epigenetic modifications regulating ferroptosis and participating in the pathogenesis of COPD are discussed in order to provide reference for the treatment of COPD. |
| format | Article |
| id | doaj-art-bbb3225f708b43c4961e141c878f4d14 |
| institution | OA Journals |
| issn | 1005-930X |
| language | zho |
| publishDate | 2024-08-01 |
| publisher | Editorial Office of Journal of Guangxi Medical University |
| record_format | Article |
| series | Guangxi Yike Daxue xuebao |
| spelling | doaj-art-bbb3225f708b43c4961e141c878f4d142025-08-20T02:15:20ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2024-08-014181206121210.16190/j.cnki.45-1211/r.2024.08.015gxykdxxb-41-8-1206Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary diseaseCAI Xiaoyu0GAO Feng1HUANG Bin2QIN Huiping3Guilin Medical University, Guilin 541199, ChinaGuilin People's Hospital Affiliated to Guilin Medical University, Guilin 541002, ChinaGuilin People's Hospital Affiliated to Guilin Medical University, Guilin 541002, ChinaGuilin Medical University, Guilin 541199, ChinaFerroptosis is a special type of programmed cell death, which is different from autophagy, apoptosis and other modes of death, and characterized by mitochondrial shrinkage, membrane density increase and ridge reduction. The mechanism of ferroptosis is mainly related to the dysregulation of intracellular iron metabolism system, lipid peroxidation, and reduction of glutathione. Chronic obstructive pulmonary disease (COPD) has developed into a serious chronic respiratory disease threatening human health. Chronic inflammation, oxidative stress, and protease/antiprotease imbalance caused by inhalation of tobacco or other atmospheric particles contribute to the development of COPD. Epigenetic modifications affect the heritable expression of genes through histone or nucleic acid sequence modification, and regulate the expression of genes in the ferroptosis-related pathway to amplify or inhibit the role of ferroptosis in COPD. These modifications provide potential therapeutic targets for the disease progression. In this paper, the mechanism of ferroptosis, the relationship between ferroptosis and COPD, and epigenetic modifications regulating ferroptosis and participating in the pathogenesis of COPD are discussed in order to provide reference for the treatment of COPD.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.08.015ferroptosischronic obstructive pulmonary diseaselipid peroxidationepigenetic modification |
| spellingShingle | CAI Xiaoyu GAO Feng HUANG Bin QIN Huiping Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease Guangxi Yike Daxue xuebao ferroptosis chronic obstructive pulmonary disease lipid peroxidation epigenetic modification |
| title | Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease |
| title_full | Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease |
| title_fullStr | Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease |
| title_full_unstemmed | Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease |
| title_short | Progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease |
| title_sort | progress in epigenetic modification of ferroptosis involved in chronic obstructive pulmonary disease |
| topic | ferroptosis chronic obstructive pulmonary disease lipid peroxidation epigenetic modification |
| url | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.08.015 |
| work_keys_str_mv | AT caixiaoyu progressinepigeneticmodificationofferroptosisinvolvedinchronicobstructivepulmonarydisease AT gaofeng progressinepigeneticmodificationofferroptosisinvolvedinchronicobstructivepulmonarydisease AT huangbin progressinepigeneticmodificationofferroptosisinvolvedinchronicobstructivepulmonarydisease AT qinhuiping progressinepigeneticmodificationofferroptosisinvolvedinchronicobstructivepulmonarydisease |