Immune reconstitution of human cytomegalovirus-specific T lymphocytes after allogeneic hematopoietic stem cell transplantation and their predictive role in reactivation

Immune reconstitution of human cytomegalovirus-specific T lymphocytes after allogeneic hematopoietic stem cell transplantation and their predictive role in reactivation

Human cytomegalovirus (HCMV) is the most common virus to affect the recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). HCMV reactivation increases the risk of secondary fungal and bacterial infections, as well as that of non-relapse mortality after allo-HSCT. This study in...

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Main Authors: Yuanqi Zhao, Sisi Zhen, Jiali Wang, Jieru Wang, Runzhi Ma, Li Liu, Aiming Pang, Rongli Zhang, Xin Chen, Weihua Zhai, Donglin Yang, Yi He, Mingzhe Han, Erlie Jiang, Sizhou Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
cytomegalovirus
hematopoietic stem cell transplantation
immune monitoring
pre-emptive therapy
infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1464096/full
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