Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes
Purpose: To review the clinical features, risk factors, microbiological profile, and treatment regimens of fungal keratitis in Galicia, a region in Northwestern Spain with temperate humid weather. Patients and methods: A retrospective case series was employed, including patients with fungal keratiti...
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MDPI AG
2024-10-01
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| author | David Lamas-Francis Daniel Navarro Raquel Mansilla Victoria de-Rojas Claudio Moreno Enrique Dios Jesús Rigueiro Dolores Álvarez Paloma Crego Teresa Rodríguez-Ares Rosario Touriño |
| author_facet | David Lamas-Francis Daniel Navarro Raquel Mansilla Victoria de-Rojas Claudio Moreno Enrique Dios Jesús Rigueiro Dolores Álvarez Paloma Crego Teresa Rodríguez-Ares Rosario Touriño |
| author_sort | David Lamas-Francis |
| collection | DOAJ |
| description | Purpose: To review the clinical features, risk factors, microbiological profile, and treatment regimens of fungal keratitis in Galicia, a region in Northwestern Spain with temperate humid weather. Patients and methods: A retrospective case series was employed, including patients with fungal keratitis from nine hospitals within the region of Galicia, Spain, between 2010 and 2020. Data obtained from clinical records were analysed. Results: Out of 654 cases of infectious keratitis, 77 cases (9.9%) were identified as fungal keratitis. The median age of affected patients was 68.0 years, with a higher incidence in rural areas (62.3%). <i>Candida</i> spp. infections were the most frequent type (55.8%) and were associated with a higher median age than were the non-dermatophyte mould infections. The primary risk factors included steroid eyedrop use (29.9%), recent keratoplasty (18.2%), ocular trauma (19.5%), and contact with vegetable matter (11.7%). Most ulcers displayed stromal involvement, and 37.7% presented corneal thinning. The median duration of infection was longer in fungal than in bacterial keratitis, and surgical intervention was required in 48.1% of cases. Conclusions: Fungal keratitis, mainly involving <i>Candida</i> spp., accounted for 9.9% of microbial keratitis cases in Galicia, Spain, with significant risk factors being topical steroid use, ocular trauma, and contact with vegetable matter. Delayed diagnosis often resulted in poor outcomes, highlighting the need for early detection through awareness and new technologies to improve prognosis. |
| format | Article |
| id | doaj-art-bbb01561ef8c425380e65fea610eef45 |
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| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Journal of Fungi |
| spelling | doaj-art-bbb01561ef8c425380e65fea610eef452025-08-20T02:10:54ZengMDPI AGJournal of Fungi2309-608X2024-10-01101068910.3390/jof10100689Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and OutcomesDavid Lamas-Francis0Daniel Navarro1Raquel Mansilla2Victoria de-Rojas3Claudio Moreno4Enrique Dios5Jesús Rigueiro6Dolores Álvarez7Paloma Crego8Teresa Rodríguez-Ares9Rosario Touriño10Department of Ophthalmology, University Hospital of Santiago de Compostela, Ramón Baltar s/n, 15706 Santiago de Compostela, SpainDepartment of Microbiology, University Hospital of Santiago de Compostela, 15706 Santiago de Compostela, SpainDepartment of Ophthalmology, University Hospital of Vigo, 36312 Vigo, SpainDepartment of Ophthalmology, University Hospital of A Coruña, 15006 A Coruña, SpainDepartment of Ophthalmology, University Hospital of Ourense, 32005 Ourense, SpainDepartment of Ophthalmology, University Hospital of Pontevedra, 36161 Pontevedra, SpainDepartment of Ophthalmology, University Hospital Lucus Augusti, 27003 Lugo, SpainDepartment of Ophthalmology, University Hospital of Ferrol, 15401 Ferrol, SpainDepartment of Ophthalmology, Hospital Público da Mariña, 27880 Burela, SpainDepartment of Ophthalmology, University Hospital of Santiago de Compostela, Ramón Baltar s/n, 15706 Santiago de Compostela, SpainDepartment of Ophthalmology, University Hospital of Santiago de Compostela, Ramón Baltar s/n, 15706 Santiago de Compostela, SpainPurpose: To review the clinical features, risk factors, microbiological profile, and treatment regimens of fungal keratitis in Galicia, a region in Northwestern Spain with temperate humid weather. Patients and methods: A retrospective case series was employed, including patients with fungal keratitis from nine hospitals within the region of Galicia, Spain, between 2010 and 2020. Data obtained from clinical records were analysed. Results: Out of 654 cases of infectious keratitis, 77 cases (9.9%) were identified as fungal keratitis. The median age of affected patients was 68.0 years, with a higher incidence in rural areas (62.3%). <i>Candida</i> spp. infections were the most frequent type (55.8%) and were associated with a higher median age than were the non-dermatophyte mould infections. The primary risk factors included steroid eyedrop use (29.9%), recent keratoplasty (18.2%), ocular trauma (19.5%), and contact with vegetable matter (11.7%). Most ulcers displayed stromal involvement, and 37.7% presented corneal thinning. The median duration of infection was longer in fungal than in bacterial keratitis, and surgical intervention was required in 48.1% of cases. Conclusions: Fungal keratitis, mainly involving <i>Candida</i> spp., accounted for 9.9% of microbial keratitis cases in Galicia, Spain, with significant risk factors being topical steroid use, ocular trauma, and contact with vegetable matter. Delayed diagnosis often resulted in poor outcomes, highlighting the need for early detection through awareness and new technologies to improve prognosis.https://www.mdpi.com/2309-608X/10/10/689keratitiscorneafungi |
| spellingShingle | David Lamas-Francis Daniel Navarro Raquel Mansilla Victoria de-Rojas Claudio Moreno Enrique Dios Jesús Rigueiro Dolores Álvarez Paloma Crego Teresa Rodríguez-Ares Rosario Touriño Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes Journal of Fungi keratitis cornea fungi |
| title | Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes |
| title_full | Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes |
| title_fullStr | Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes |
| title_full_unstemmed | Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes |
| title_short | Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes |
| title_sort | fungal keratitis in northwestern spain epidemiology risk factors and outcomes |
| topic | keratitis cornea fungi |
| url | https://www.mdpi.com/2309-608X/10/10/689 |
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