Bone marrow mesenchymal stem cells transport connexin43 via tunneling nanotubes to alleviate isopreterenol-induced myocardial hypertrophy

Bone marrow mesenchymal stem cells transport connexin43 via tunneling nanotubes to alleviate isopreterenol-induced myocardial hypertrophy

Abstract Background Paracrine signaling plays an important role in stem cell therapy. However, it alone cannot fully explain the therapeutic mechanisms of stem cell therapy in treating heart diseases. Recently, tunneling nanotubes (TNTs)—a novel type of long-distance intercellular connectional struc...

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Bibliographic Details
Main Authors: Jianghui Zhang, Hongfeng Jiang, Sa Liu, Zhong Xian, Limin Zhao, Yue Li, Wenxiu Lu, Changrong Shao, Sanbao Chai
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Cardiomyocytes
Tunneling nanotubes
Connexin43
Myocardial hypertrophy
Online Access:https://doi.org/10.1186/s13287-025-04339-w
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