Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy
The treatment of Helicobacter pylori infection remains a challenge. None of the proposed treatment regimens has resulted in a 100% eradication rate. The aim of our study was to compare the rate of H. pylori eradication after standard or dose-optimized amoxicillin quadruple therapy. We conducted a pr...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0316 |
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| author | Salma Souissi Cyrine Makni Basma Chaieb Amine Jarraya Nadia Toulgui Lobna Jmal Mouna Mlika Chadlia Fendri Mohamed Bouchoucha Rabie Razgallah Leila Belhadj Ammar Olfa Bousnina Fawzi Mezni Awatef Jmal Lamia Kallel |
| author_facet | Salma Souissi Cyrine Makni Basma Chaieb Amine Jarraya Nadia Toulgui Lobna Jmal Mouna Mlika Chadlia Fendri Mohamed Bouchoucha Rabie Razgallah Leila Belhadj Ammar Olfa Bousnina Fawzi Mezni Awatef Jmal Lamia Kallel |
| author_sort | Salma Souissi |
| collection | DOAJ |
| description | The treatment of Helicobacter pylori infection remains a challenge. None of the proposed treatment regimens has resulted in a 100% eradication rate. The aim of our study was to compare the rate of H. pylori eradication after standard or dose-optimized amoxicillin quadruple therapy. We conducted a prospective comparative study collating patients naive to any anti-H. pylori treatment and with chronic H. pylori infection documented by histological examination. Patients were randomly assigned to either standard quadruple therapy or optimized quadruple therapy. Eradication control was performed by urea breath test. Eighty-eight eligible patients were included with 44 in each group.There was no significant difference between the eradication rates of Qo-14 and Qs-14 neither in ITT (84 vs 70.4%; p = 0.127) nor in PP (82.1 vs 77.7%; p = 0.473). Compliance and tolerance appeared similar in each group. |
| format | Article |
| id | doaj-art-bba81528aece40bf9e726de7f1550964 |
| institution | DOAJ |
| issn | 2056-5623 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-bba81528aece40bf9e726de7f15509642025-08-20T02:41:39ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.2144/fsoa-2023-0316Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapySalma Souissi0Cyrine Makni1Basma Chaieb2Amine Jarraya3Nadia Toulgui4Lobna Jmal5Mouna Mlika6Chadlia Fendri7Mohamed Bouchoucha8Rabie Razgallah9Leila Belhadj Ammar10Olfa Bousnina11Fawzi Mezni12Awatef Jmal13Lamia Kallel14University of Tunis El Manar, Departement of Gastroenterology, Mahmoud Matri Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Gastroenterology, Mahmoud Matri Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Gastroenterology, Mahmoud Matri Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Gastroenterology, Mahmoud Matri Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Gastroenterology, Mahmoud Matri Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Bacteriology & Biochemistry Laboratory, Mahmoud Matri Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Anatomopathology, Abderrahmen Mami Hospital, Ariana, 2080, TunisiaClinical Analysis Laboratory “Fendri”, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Dacima Consulting, Tunis, 2080, TunisiaUniversity of Tunis El Manar, Dacima Consulting, Tunis, 2080, TunisiaUniversity of Tunis El Manar, Departement of Gastroenterology, Mahmoud Matri Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Gastroenterology, Mahmoud Matri Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Anatomopathology, Abderrahmen Mami Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Bacteriology & Biochemistry Laboratory, Mahmoud Matri Hospital, Ariana, 2080, TunisiaUniversity of Tunis El Manar, Departement of Gastroenterology, Mahmoud Matri Hospital, Ariana, 2080, TunisiaThe treatment of Helicobacter pylori infection remains a challenge. None of the proposed treatment regimens has resulted in a 100% eradication rate. The aim of our study was to compare the rate of H. pylori eradication after standard or dose-optimized amoxicillin quadruple therapy. We conducted a prospective comparative study collating patients naive to any anti-H. pylori treatment and with chronic H. pylori infection documented by histological examination. Patients were randomly assigned to either standard quadruple therapy or optimized quadruple therapy. Eradication control was performed by urea breath test. Eighty-eight eligible patients were included with 44 in each group.There was no significant difference between the eradication rates of Qo-14 and Qs-14 neither in ITT (84 vs 70.4%; p = 0.127) nor in PP (82.1 vs 77.7%; p = 0.473). Compliance and tolerance appeared similar in each group.https://www.tandfonline.com/doi/10.2144/fsoa-2023-0316eradicationHelicobacter pyloriquadruple therapy |
| spellingShingle | Salma Souissi Cyrine Makni Basma Chaieb Amine Jarraya Nadia Toulgui Lobna Jmal Mouna Mlika Chadlia Fendri Mohamed Bouchoucha Rabie Razgallah Leila Belhadj Ammar Olfa Bousnina Fawzi Mezni Awatef Jmal Lamia Kallel Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy Future Science OA eradication Helicobacter pylori quadruple therapy |
| title | Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy |
| title_full | Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy |
| title_fullStr | Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy |
| title_full_unstemmed | Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy |
| title_short | Eradication of Helicobacter pylori: a prospective comparative randomized trial of standard versus optimized quadruple therapy |
| title_sort | eradication of helicobacter pylori a prospective comparative randomized trial of standard versus optimized quadruple therapy |
| topic | eradication Helicobacter pylori quadruple therapy |
| url | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0316 |
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