Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer
Prostate cancer (PCa) is one of the most common malignancies found in males. The development of PCa involves several mutations in prostate epithelial cells, usually linked to developmental changes, such as enhanced resistance to apoptotic death, constitutive proliferation, and, in some cases, to dif...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/920612 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849685936169811968 |
|---|---|
| author | Henrique B. da Silva Eduardo P. Amaral Eduardo L. Nolasco Nathalia C. de Victo Rodrigo Atique Carina C. Jank Valesca Anschau Luiz F. Zerbini Ricardo G. Correa |
| author_facet | Henrique B. da Silva Eduardo P. Amaral Eduardo L. Nolasco Nathalia C. de Victo Rodrigo Atique Carina C. Jank Valesca Anschau Luiz F. Zerbini Ricardo G. Correa |
| author_sort | Henrique B. da Silva |
| collection | DOAJ |
| description | Prostate cancer (PCa) is one of the most common malignancies found in males. The development of PCa involves several mutations in prostate epithelial cells, usually linked to developmental changes, such as enhanced resistance to apoptotic death, constitutive proliferation, and, in some cases, to differentiation into an androgen deprivation-resistant phenotype, leading to the appearance of castration-resistant PCa (CRPCa), which leads to a poor prognosis in patients. In this review, we summarize recent findings concerning the main deregulations into signaling pathways that will lead to the development of PCa and/or CRPCa. Key mutations in some pathway molecules are often linked to a higher prevalence of PCa, by directly affecting the respective cascade and, in some cases, by deregulating a cross-talk node or junction along the pathways. We also discuss the possible environmental and nonenvironmental inducers for these mutations, as well as the potential therapeutic strategies targeting these signaling pathways. A better understanding of how some risk factors induce deregulation of these signaling pathways, as well as how these deregulated pathways affect the development of PCa and CRPCa, will further help in the development of new treatments and prevention strategies for this disease. |
| format | Article |
| id | doaj-art-bba7e266f6424e5fac6fb2cd8f695152 |
| institution | DOAJ |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-bba7e266f6424e5fac6fb2cd8f6951522025-08-20T03:22:54ZengWileyProstate Cancer2090-31112090-312X2013-01-01201310.1155/2013/920612920612Dissecting Major Signaling Pathways throughout the Development of Prostate CancerHenrique B. da Silva0Eduardo P. Amaral1Eduardo L. Nolasco2Nathalia C. de Victo3Rodrigo Atique4Carina C. Jank5Valesca Anschau6Luiz F. Zerbini7Ricardo G. Correa8Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Prof. Lineu Prestes 1730, 05508-900 São Paulo, SP, BrazilDepartamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Prof. Lineu Prestes 1730, 05508-900 São Paulo, SP, BrazilDepartamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Avenida Prof. Lineu Prestes 580, 05508-000 São Paulo, SP, BrazilDepartamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Prof. Lineu Prestes 1730, 05508-900 São Paulo, SP, BrazilDepartamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, Rua do Matão 277, 05508-900 São Paulo, SP, BrazilDepartamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Prof. Lineu Prestes 1730, 05508-900 São Paulo, SP, BrazilDepartamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, Rua do Matão 277, 05508-900 São Paulo, SP, BrazilInternational Center for Genetic Engineering & Biotechnology (ICGEB), Cancer Genomics Group and Division of Medical Biochemistry, University of Cape Town, Cape Town 7925, South AfricaSanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USAProstate cancer (PCa) is one of the most common malignancies found in males. The development of PCa involves several mutations in prostate epithelial cells, usually linked to developmental changes, such as enhanced resistance to apoptotic death, constitutive proliferation, and, in some cases, to differentiation into an androgen deprivation-resistant phenotype, leading to the appearance of castration-resistant PCa (CRPCa), which leads to a poor prognosis in patients. In this review, we summarize recent findings concerning the main deregulations into signaling pathways that will lead to the development of PCa and/or CRPCa. Key mutations in some pathway molecules are often linked to a higher prevalence of PCa, by directly affecting the respective cascade and, in some cases, by deregulating a cross-talk node or junction along the pathways. We also discuss the possible environmental and nonenvironmental inducers for these mutations, as well as the potential therapeutic strategies targeting these signaling pathways. A better understanding of how some risk factors induce deregulation of these signaling pathways, as well as how these deregulated pathways affect the development of PCa and CRPCa, will further help in the development of new treatments and prevention strategies for this disease.http://dx.doi.org/10.1155/2013/920612 |
| spellingShingle | Henrique B. da Silva Eduardo P. Amaral Eduardo L. Nolasco Nathalia C. de Victo Rodrigo Atique Carina C. Jank Valesca Anschau Luiz F. Zerbini Ricardo G. Correa Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer Prostate Cancer |
| title | Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer |
| title_full | Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer |
| title_fullStr | Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer |
| title_full_unstemmed | Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer |
| title_short | Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer |
| title_sort | dissecting major signaling pathways throughout the development of prostate cancer |
| url | http://dx.doi.org/10.1155/2013/920612 |
| work_keys_str_mv | AT henriquebdasilva dissectingmajorsignalingpathwaysthroughoutthedevelopmentofprostatecancer AT eduardopamaral dissectingmajorsignalingpathwaysthroughoutthedevelopmentofprostatecancer AT eduardolnolasco dissectingmajorsignalingpathwaysthroughoutthedevelopmentofprostatecancer AT nathaliacdevicto dissectingmajorsignalingpathwaysthroughoutthedevelopmentofprostatecancer AT rodrigoatique dissectingmajorsignalingpathwaysthroughoutthedevelopmentofprostatecancer AT carinacjank dissectingmajorsignalingpathwaysthroughoutthedevelopmentofprostatecancer AT valescaanschau dissectingmajorsignalingpathwaysthroughoutthedevelopmentofprostatecancer AT luizfzerbini dissectingmajorsignalingpathwaysthroughoutthedevelopmentofprostatecancer AT ricardogcorrea dissectingmajorsignalingpathwaysthroughoutthedevelopmentofprostatecancer |