Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice

Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice

ABSTRACT Aims/Introduction We previously showed that glucokinase haploinsufficiency improves the glucose tolerance of db/db mice by preserving pancreatic β‐cell mass and function. In the present study, we aimed to determine the effects of glucokinase haploinsufficiency on the β‐cell mass and functio...

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Bibliographic Details
Main Authors: Ikumi Shigesawa, Akinobu Nakamura, Yuki Yamauchi, Shinichiro Kawata, Asuka Miyazaki, Hiroshi Nomoto, Hiraku Kameda, Yasuo Terauchi, Tatsuya Atsumi
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of Diabetes Investigation
Subjects:
β‐cell mass
Glucokinase
Glucose‐stimulated insulin secretion
Online Access:https://doi.org/10.1111/jdi.14307
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