Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/1798285 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850178419401162752 |
|---|---|
| author | Guo-Chen Liu Jun-Ping Yan Qing He Xin An Zhi-Zhong Pan Pei-Rong Ding |
| author_facet | Guo-Chen Liu Jun-Ping Yan Qing He Xin An Zhi-Zhong Pan Pei-Rong Ding |
| author_sort | Guo-Chen Liu |
| collection | DOAJ |
| description | A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014. Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion. RevMan software was used to analyze these data. Nine trials were included in this meta-analysis, which covered a total of 3141 patients. The meta-analysis showed that capecitabine group had statistically significant better pCR rates (OR, 1.34; 95% CI, 1.10–1.64; P=0.003), T downstaging rates (OR, 1.58; 95% CI, 1.22–2.06; P=0.0007), N downstaging rates (OR, 2.06; 95% CI, 1.34–3.16; P=0.001), less distant metastasis (OR, 0.63; 95% CI, 0.44–0.88; P=0.007), and lowered leucocytes (OR, 0.25; 95% CI, 0.11–0.54; P=0.0005), but with higher incidence of hand-foot syndrome (HFS) (OR, 4.43; 95% CI, 1.59–12.33; P=0.004). Capecitabine was more efficient than 5-FU in terms of tumor response in neoadjuvant treatment for patients with LARC and favourably low toxicity with the exception of HFS. |
| format | Article |
| id | doaj-art-bb9fa0cf26d4494699ffb8ac616f21cd |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-bb9fa0cf26d4494699ffb8ac616f21cd2025-08-20T02:18:43ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/17982851798285Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-AnalysisGuo-Chen Liu0Jun-Ping Yan1Qing He2Xin An3Zhi-Zhong Pan4Pei-Rong Ding5Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong 510060, ChinaDepartment of Laboratory Medicine, Guangdong No. 2 Provincial People’s Hospital, Guangdong, ChinaDepartment of General Surgery, People’s Hospital of Yuxi City, Yunnan, ChinaDepartment of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong, ChinaDepartment of Colorectal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong 510060, ChinaDepartment of Colorectal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong 510060, ChinaA meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014. Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion. RevMan software was used to analyze these data. Nine trials were included in this meta-analysis, which covered a total of 3141 patients. The meta-analysis showed that capecitabine group had statistically significant better pCR rates (OR, 1.34; 95% CI, 1.10–1.64; P=0.003), T downstaging rates (OR, 1.58; 95% CI, 1.22–2.06; P=0.0007), N downstaging rates (OR, 2.06; 95% CI, 1.34–3.16; P=0.001), less distant metastasis (OR, 0.63; 95% CI, 0.44–0.88; P=0.007), and lowered leucocytes (OR, 0.25; 95% CI, 0.11–0.54; P=0.0005), but with higher incidence of hand-foot syndrome (HFS) (OR, 4.43; 95% CI, 1.59–12.33; P=0.004). Capecitabine was more efficient than 5-FU in terms of tumor response in neoadjuvant treatment for patients with LARC and favourably low toxicity with the exception of HFS.http://dx.doi.org/10.1155/2016/1798285 |
| spellingShingle | Guo-Chen Liu Jun-Ping Yan Qing He Xin An Zhi-Zhong Pan Pei-Rong Ding Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis Gastroenterology Research and Practice |
| title | Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis |
| title_full | Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis |
| title_fullStr | Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis |
| title_full_unstemmed | Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis |
| title_short | Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis |
| title_sort | effect of neoadjuvant chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer a meta analysis |
| url | http://dx.doi.org/10.1155/2016/1798285 |
| work_keys_str_mv | AT guochenliu effectofneoadjuvantchemoradiotherapywithcapecitabineversusfluorouracilforlocallyadvancedrectalcancerametaanalysis AT junpingyan effectofneoadjuvantchemoradiotherapywithcapecitabineversusfluorouracilforlocallyadvancedrectalcancerametaanalysis AT qinghe effectofneoadjuvantchemoradiotherapywithcapecitabineversusfluorouracilforlocallyadvancedrectalcancerametaanalysis AT xinan effectofneoadjuvantchemoradiotherapywithcapecitabineversusfluorouracilforlocallyadvancedrectalcancerametaanalysis AT zhizhongpan effectofneoadjuvantchemoradiotherapywithcapecitabineversusfluorouracilforlocallyadvancedrectalcancerametaanalysis AT peirongding effectofneoadjuvantchemoradiotherapywithcapecitabineversusfluorouracilforlocallyadvancedrectalcancerametaanalysis |