Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown.
In utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much train...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0098439 |
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| _version_ | 1850162941063593984 |
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| author | Tracy M Centanni Fuyi Chen Anne M Booker Crystal T Engineer Andrew M Sloan Robert L Rennaker Joseph J LoTurco Michael P Kilgard |
| author_facet | Tracy M Centanni Fuyi Chen Anne M Booker Crystal T Engineer Andrew M Sloan Robert L Rennaker Joseph J LoTurco Michael P Kilgard |
| author_sort | Tracy M Centanni |
| collection | DOAJ |
| description | In utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much training in quiet conditions to perform at control levels and remained impaired at several speech tasks. Focused training using truncated speech sounds was able to normalize speech discrimination in quiet and background noise conditions. Training also normalized trial-by-trial neural variability and temporal phase locking. Cortical activity from speech trained KIA- rats was sufficient to accurately discriminate between similar consonant sounds. These results provide the first direct evidence that assumed reduced expression of the dyslexia-associated gene KIAA0319 can cause phoneme processing impairments similar to those seen in dyslexia and that intensive behavioral therapy can eliminate these impairments. |
| format | Article |
| id | doaj-art-bb9f33bb24d04819a98f4f4a4fefefd8 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-bb9f33bb24d04819a98f4f4a4fefefd82025-08-20T02:22:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9843910.1371/journal.pone.0098439Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown.Tracy M CentanniFuyi ChenAnne M BookerCrystal T EngineerAndrew M SloanRobert L RennakerJoseph J LoTurcoMichael P KilgardIn utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much training in quiet conditions to perform at control levels and remained impaired at several speech tasks. Focused training using truncated speech sounds was able to normalize speech discrimination in quiet and background noise conditions. Training also normalized trial-by-trial neural variability and temporal phase locking. Cortical activity from speech trained KIA- rats was sufficient to accurately discriminate between similar consonant sounds. These results provide the first direct evidence that assumed reduced expression of the dyslexia-associated gene KIAA0319 can cause phoneme processing impairments similar to those seen in dyslexia and that intensive behavioral therapy can eliminate these impairments.https://doi.org/10.1371/journal.pone.0098439 |
| spellingShingle | Tracy M Centanni Fuyi Chen Anne M Booker Crystal T Engineer Andrew M Sloan Robert L Rennaker Joseph J LoTurco Michael P Kilgard Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown. PLoS ONE |
| title | Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown. |
| title_full | Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown. |
| title_fullStr | Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown. |
| title_full_unstemmed | Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown. |
| title_short | Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown. |
| title_sort | speech sound processing deficits and training induced neural plasticity in rats with dyslexia gene knockdown |
| url | https://doi.org/10.1371/journal.pone.0098439 |
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