Histone H1 plays a role in heterochromatin formation and VSG expression site silencing in Trypanosoma brucei.

Histone H1 plays a role in heterochromatin formation and VSG expression site silencing in Trypanosoma brucei.

The African sleeping sickness parasite Trypanosoma brucei evades the host immune system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although the T. brucei genome contains ∼1500 VSGs, only one VSG is expressed at a time from one of about 15 subtelomeric VSG expression...

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Bibliographic Details
Main Authors: Megan L Povelones, Eva Gluenz, Marcin Dembek, Keith Gull, Gloria Rudenko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003010&type=printable
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