Oil-in-water segmented flow in the optimized microfluidic system for surfactant-free ultrasonic emulsification
Abstract Droplet-based microfluidics is a promising technique for generating stable emulsions in various applications, including pharmaceuticals, food, cosmetics, and biosensors. However, conventional methods rely on surfactants, which pose potential toxicity and environmental concerns. To address t...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-08650-7 |
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| author | Hyeonji Hong Eunbi Lee Seonae Hwangbo Il Doh |
| author_facet | Hyeonji Hong Eunbi Lee Seonae Hwangbo Il Doh |
| author_sort | Hyeonji Hong |
| collection | DOAJ |
| description | Abstract Droplet-based microfluidics is a promising technique for generating stable emulsions in various applications, including pharmaceuticals, food, cosmetics, and biosensors. However, conventional methods rely on surfactants, which pose potential toxicity and environmental concerns. To address this issue, we developed a microfluidic device for surfactant-free oil droplet generation, serving as a pre-processing stage for ultrasonic emulsification. Three microfluidic channels were designed: a conventional T-junction, a needle-inserted channel, and a needle-inserted glass capillary channel. Oil-water flow segmentation characteristics of the fabricated devices were analyzed using high-speed camera and image processing techniques. Results demonstrated that the needle-inserted glass capillary exhibited superior stability, effectively generating oil droplets rather than slugs by utilizing a higher water affinity and minimizing oil contact with the channel walls. Furthermore, when integrated with ultrasonic emulsification, the pre-fragmented oil droplets exhibited improved processing efficiency. These findings highlight the potential of combining microfluidic pre-processing with ultrasound emulsification as a viable alternative to surfactant-based methods, offering enhanced precision and sustainability in droplet generation and emulsion formation. |
| format | Article |
| id | doaj-art-bb9c5f2b2e18400bb44e3e1bb8b6c799 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-bb9c5f2b2e18400bb44e3e1bb8b6c7992025-08-20T03:03:25ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-08650-7Oil-in-water segmented flow in the optimized microfluidic system for surfactant-free ultrasonic emulsificationHyeonji Hong0Eunbi Lee1Seonae Hwangbo2Il Doh3Medical Metrology Group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS)Focused Ultra-Sonic Tech. Lab. (FUST Lab) Co., Ltd.Focused Ultra-Sonic Tech. Lab. (FUST Lab) Co., Ltd.Medical Metrology Group, Division of Biomedical Metrology, Korea Research Institute of Standards and Science (KRISS)Abstract Droplet-based microfluidics is a promising technique for generating stable emulsions in various applications, including pharmaceuticals, food, cosmetics, and biosensors. However, conventional methods rely on surfactants, which pose potential toxicity and environmental concerns. To address this issue, we developed a microfluidic device for surfactant-free oil droplet generation, serving as a pre-processing stage for ultrasonic emulsification. Three microfluidic channels were designed: a conventional T-junction, a needle-inserted channel, and a needle-inserted glass capillary channel. Oil-water flow segmentation characteristics of the fabricated devices were analyzed using high-speed camera and image processing techniques. Results demonstrated that the needle-inserted glass capillary exhibited superior stability, effectively generating oil droplets rather than slugs by utilizing a higher water affinity and minimizing oil contact with the channel walls. Furthermore, when integrated with ultrasonic emulsification, the pre-fragmented oil droplets exhibited improved processing efficiency. These findings highlight the potential of combining microfluidic pre-processing with ultrasound emulsification as a viable alternative to surfactant-based methods, offering enhanced precision and sustainability in droplet generation and emulsion formation.https://doi.org/10.1038/s41598-025-08650-7MicrofluidicsOil-water segmented flow3D-printed chipUltrasoundEmulsification |
| spellingShingle | Hyeonji Hong Eunbi Lee Seonae Hwangbo Il Doh Oil-in-water segmented flow in the optimized microfluidic system for surfactant-free ultrasonic emulsification Scientific Reports Microfluidics Oil-water segmented flow 3D-printed chip Ultrasound Emulsification |
| title | Oil-in-water segmented flow in the optimized microfluidic system for surfactant-free ultrasonic emulsification |
| title_full | Oil-in-water segmented flow in the optimized microfluidic system for surfactant-free ultrasonic emulsification |
| title_fullStr | Oil-in-water segmented flow in the optimized microfluidic system for surfactant-free ultrasonic emulsification |
| title_full_unstemmed | Oil-in-water segmented flow in the optimized microfluidic system for surfactant-free ultrasonic emulsification |
| title_short | Oil-in-water segmented flow in the optimized microfluidic system for surfactant-free ultrasonic emulsification |
| title_sort | oil in water segmented flow in the optimized microfluidic system for surfactant free ultrasonic emulsification |
| topic | Microfluidics Oil-water segmented flow 3D-printed chip Ultrasound Emulsification |
| url | https://doi.org/10.1038/s41598-025-08650-7 |
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