Efficacy of Urovaxom for Improving Chronic Pelvic Pain Syndrome Symptoms in Prostate Cancer Patients Who Underwent Radical Prostatectomy: A Multicenter, Prospective Cohort Study
Purpose Chronic pelvic pain syndrome (CPPS) is a multifactorial condition that can significantly diminish quality of life. Although some patients have reported persistent pelvic pain after radical prostatectomy (RP), the prevalence and direct causal relationship between CPPS and RP remain unclear. T...
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Korean Association of Urogenital Tract Infection and Inflammation
2025-04-01
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| Series: | Urogenital Tract Infection |
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| Online Access: | http://euti.org/upload/pdf/uti-2550014007.pdf |
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| author | Jun-Koo Kang Yun-Sok Ha Sungchan Park Tae Gyun Kwon Tae-Hwan Kim |
| author_facet | Jun-Koo Kang Yun-Sok Ha Sungchan Park Tae Gyun Kwon Tae-Hwan Kim |
| author_sort | Jun-Koo Kang |
| collection | DOAJ |
| description | Purpose Chronic pelvic pain syndrome (CPPS) is a multifactorial condition that can significantly diminish quality of life. Although some patients have reported persistent pelvic pain after radical prostatectomy (RP), the prevalence and direct causal relationship between CPPS and RP remain unclear. This multicenter prospective study aimed to evaluate the efficacy of Urovaxom for improving CPPS symptoms. Materials and Methods A total of 52 prostate cancer patients who underwent RP were enrolled and administered Urovaxom (60 mg/day) for 12 weeks. Changes in National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), overactive bladder symptom score (OABSS), International Prostate Symptom Score (IPSS), and inflammation markers (white blood cell [WBC], C-reactive protein [CRP]) were analyzed using the Wilcoxon signed-rank test. Results After 12 weeks of treatment, the NIH-CPSI total score significantly decreased from 19 (interquartile range [IQR], 16–23) to 12.5 (IQR, 8.0–16.8) (p<0.001). The OABSS total score decreased from 8 (IQR, 4–11) to 5 (IQR, 3.0–7.8), and the IPSS total score decreased from 13.5 (IQR, 10.0–22.8) to 10.5 (IQR, 5.0–17.0) (p<0.001). WBC levels showed a slight increase (p=0.028), but the clinical relevance of this change is uncertain and warrants further investigation. CRP changes were not statistically significant (p=0.274). Conclusions Urovaxom demonstrated significant efficacy in improving CPPS symptoms, particularly pain and reduced quality of life, in patients following RP. These findings suggest Urovaxom as a potential therapeutic option for CPPS after management using RP. |
| format | Article |
| id | doaj-art-bb97a71404564687be900c68df36dc65 |
| institution | DOAJ |
| issn | 2465-8243 2465-8510 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Korean Association of Urogenital Tract Infection and Inflammation |
| record_format | Article |
| series | Urogenital Tract Infection |
| spelling | doaj-art-bb97a71404564687be900c68df36dc652025-08-20T02:47:33ZengKorean Association of Urogenital Tract Infection and InflammationUrogenital Tract Infection2465-82432465-85102025-04-01201424710.14777/uti.2550014007434Efficacy of Urovaxom for Improving Chronic Pelvic Pain Syndrome Symptoms in Prostate Cancer Patients Who Underwent Radical Prostatectomy: A Multicenter, Prospective Cohort StudyJun-Koo Kang0Yun-Sok Ha1Sungchan Park2Tae Gyun Kwon3Tae-Hwan Kim4 Department of Urology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea Department of Urology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea Department of Urology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea Department of Urology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, KoreaPurpose Chronic pelvic pain syndrome (CPPS) is a multifactorial condition that can significantly diminish quality of life. Although some patients have reported persistent pelvic pain after radical prostatectomy (RP), the prevalence and direct causal relationship between CPPS and RP remain unclear. This multicenter prospective study aimed to evaluate the efficacy of Urovaxom for improving CPPS symptoms. Materials and Methods A total of 52 prostate cancer patients who underwent RP were enrolled and administered Urovaxom (60 mg/day) for 12 weeks. Changes in National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), overactive bladder symptom score (OABSS), International Prostate Symptom Score (IPSS), and inflammation markers (white blood cell [WBC], C-reactive protein [CRP]) were analyzed using the Wilcoxon signed-rank test. Results After 12 weeks of treatment, the NIH-CPSI total score significantly decreased from 19 (interquartile range [IQR], 16–23) to 12.5 (IQR, 8.0–16.8) (p<0.001). The OABSS total score decreased from 8 (IQR, 4–11) to 5 (IQR, 3.0–7.8), and the IPSS total score decreased from 13.5 (IQR, 10.0–22.8) to 10.5 (IQR, 5.0–17.0) (p<0.001). WBC levels showed a slight increase (p=0.028), but the clinical relevance of this change is uncertain and warrants further investigation. CRP changes were not statistically significant (p=0.274). Conclusions Urovaxom demonstrated significant efficacy in improving CPPS symptoms, particularly pain and reduced quality of life, in patients following RP. These findings suggest Urovaxom as a potential therapeutic option for CPPS after management using RP.http://euti.org/upload/pdf/uti-2550014007.pdfchronic pelvic pain syndromeurovaxomprostatectomyquality of lifenational institutes of health chronic prostatitis symptom index |
| spellingShingle | Jun-Koo Kang Yun-Sok Ha Sungchan Park Tae Gyun Kwon Tae-Hwan Kim Efficacy of Urovaxom for Improving Chronic Pelvic Pain Syndrome Symptoms in Prostate Cancer Patients Who Underwent Radical Prostatectomy: A Multicenter, Prospective Cohort Study Urogenital Tract Infection chronic pelvic pain syndrome urovaxom prostatectomy quality of life national institutes of health chronic prostatitis symptom index |
| title | Efficacy of Urovaxom for Improving Chronic Pelvic Pain Syndrome Symptoms in Prostate Cancer Patients Who Underwent Radical Prostatectomy: A Multicenter, Prospective Cohort Study |
| title_full | Efficacy of Urovaxom for Improving Chronic Pelvic Pain Syndrome Symptoms in Prostate Cancer Patients Who Underwent Radical Prostatectomy: A Multicenter, Prospective Cohort Study |
| title_fullStr | Efficacy of Urovaxom for Improving Chronic Pelvic Pain Syndrome Symptoms in Prostate Cancer Patients Who Underwent Radical Prostatectomy: A Multicenter, Prospective Cohort Study |
| title_full_unstemmed | Efficacy of Urovaxom for Improving Chronic Pelvic Pain Syndrome Symptoms in Prostate Cancer Patients Who Underwent Radical Prostatectomy: A Multicenter, Prospective Cohort Study |
| title_short | Efficacy of Urovaxom for Improving Chronic Pelvic Pain Syndrome Symptoms in Prostate Cancer Patients Who Underwent Radical Prostatectomy: A Multicenter, Prospective Cohort Study |
| title_sort | efficacy of urovaxom for improving chronic pelvic pain syndrome symptoms in prostate cancer patients who underwent radical prostatectomy a multicenter prospective cohort study |
| topic | chronic pelvic pain syndrome urovaxom prostatectomy quality of life national institutes of health chronic prostatitis symptom index |
| url | http://euti.org/upload/pdf/uti-2550014007.pdf |
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