Multi-Target Inhibitor CUDC-101 Impairs DNA Damage Repair and Enhances Radiation Response in Triple-Negative Breast Cell Line

Multi-Target Inhibitor CUDC-101 Impairs DNA Damage Repair and Enhances Radiation Response in Triple-Negative Breast Cell Line

Background: Since the discovery that Histone deacetylase inhibitors (HDCAi) could enhance radiation response, a number of HDACi, mainly pan-HDAC inhibitors, have been studied either as monotherapy or in combination with X-ray irradiation or chemotherapeutic drugs in the management of breast cancer....

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Bibliographic Details
Main Authors: Elsie Neo Seane, Shankari Nair, Charlot Vandevoorde, Alessandra Bisio, Anna Joubert
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceuticals
Subjects:
Histone deacetylase inhibitors
CUDC-101
proton therapy
proton irradiation
Online Access:https://www.mdpi.com/1424-8247/17/11/1467
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