Synthetic mammalian transgene negative autoregulation
Abstract Biological networks contain overrepresented small‐scale topologies, typically called motifs. A frequently appearing motif is the transcriptional negative‐feedback loop, where a gene product represses its own transcription. Here, using synthetic circuits stably integrated in human kidney cel...
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| Main Authors: | Vinay Shimoga, Jacob T White, Yi Li, Eduardo Sontag, Leonidas Bleris |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2013-06-01
|
| Series: | Molecular Systems Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/msb.2013.27 |
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