Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols
Substituted phenols, including chlorophenols, are important analytes, particularly in the context of environmental analysis. Chlorophenols are formed during the disinfection of drinking water by chlorination and are important water pollutants. Gas chromatography–mass spectrometry (GC-MS) is an impor...
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2024-12-01
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| author | Anastasia Yu. Sholokhova Svetlana A. Borovikova Dmitriy D. Matyushin |
| author_facet | Anastasia Yu. Sholokhova Svetlana A. Borovikova Dmitriy D. Matyushin |
| author_sort | Anastasia Yu. Sholokhova |
| collection | DOAJ |
| description | Substituted phenols, including chlorophenols, are important analytes, particularly in the context of environmental analysis. Chlorophenols are formed during the disinfection of drinking water by chlorination and are important water pollutants. Gas chromatography–mass spectrometry (GC-MS) is an important method for the analysis of chlorophenols. Retention indices are used in GC-MS analysis to improve the accuracy of identification. Our research reveals that the retention indices currently available for substituted phenols are erroneous in a number of cases. We report reliable retention index values for pentafluorophenol, 5-methoxy-2-nitrophenol, 4-cyanophenol (stationary phase: 5%-phenyl-polymethylsiloxane), 3-methoxyphenol, 2-chlorophenol, 3-chlorophenol, 4-chlorophenol, 2,3-dichlorophenol, 2,5-dichlorophenol, 2,6-dichlorophenol, 3,4-dichlorophenol, 3,5-dichlorophenol, 2,3,5-trichlorophenol, 2,3,6-trichlorophenol, 2,4,5-trichlorophenol, and 2,4,6-trichlorophenol (stationary phase: polyethylene glycol modified with 2-nitroterephthalic acid). The structures of the standard samples were confirmed, and measurements were performed under various conditions. The analysis of the causes of the incorrect records appearing in the well-known NIST database was also carried out. |
| format | Article |
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| institution | OA Journals |
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| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-bb910eff2bc74e32a4c4c71c7924a7bb2025-08-20T02:00:51ZengMDPI AGAnalytica2673-45322024-12-015464165310.3390/analytica5040043Refinement of Retention Indices in Gas Chromatography for a Number of Substituted PhenolsAnastasia Yu. Sholokhova0Svetlana A. Borovikova1Dmitriy D. Matyushin2A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31 Leninsky Prospect, GSP-1, Moscow 119071, RussiaA.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31 Leninsky Prospect, GSP-1, Moscow 119071, RussiaA.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31 Leninsky Prospect, GSP-1, Moscow 119071, RussiaSubstituted phenols, including chlorophenols, are important analytes, particularly in the context of environmental analysis. Chlorophenols are formed during the disinfection of drinking water by chlorination and are important water pollutants. Gas chromatography–mass spectrometry (GC-MS) is an important method for the analysis of chlorophenols. Retention indices are used in GC-MS analysis to improve the accuracy of identification. Our research reveals that the retention indices currently available for substituted phenols are erroneous in a number of cases. We report reliable retention index values for pentafluorophenol, 5-methoxy-2-nitrophenol, 4-cyanophenol (stationary phase: 5%-phenyl-polymethylsiloxane), 3-methoxyphenol, 2-chlorophenol, 3-chlorophenol, 4-chlorophenol, 2,3-dichlorophenol, 2,5-dichlorophenol, 2,6-dichlorophenol, 3,4-dichlorophenol, 3,5-dichlorophenol, 2,3,5-trichlorophenol, 2,3,6-trichlorophenol, 2,4,5-trichlorophenol, and 2,4,6-trichlorophenol (stationary phase: polyethylene glycol modified with 2-nitroterephthalic acid). The structures of the standard samples were confirmed, and measurements were performed under various conditions. The analysis of the causes of the incorrect records appearing in the well-known NIST database was also carried out.https://www.mdpi.com/2673-4532/5/4/43retention indexgas chromatographychlorophenolssubstituted phenolspolyethylene glycol |
| spellingShingle | Anastasia Yu. Sholokhova Svetlana A. Borovikova Dmitriy D. Matyushin Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols Analytica retention index gas chromatography chlorophenols substituted phenols polyethylene glycol |
| title | Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols |
| title_full | Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols |
| title_fullStr | Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols |
| title_full_unstemmed | Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols |
| title_short | Refinement of Retention Indices in Gas Chromatography for a Number of Substituted Phenols |
| title_sort | refinement of retention indices in gas chromatography for a number of substituted phenols |
| topic | retention index gas chromatography chlorophenols substituted phenols polyethylene glycol |
| url | https://www.mdpi.com/2673-4532/5/4/43 |
| work_keys_str_mv | AT anastasiayusholokhova refinementofretentionindicesingaschromatographyforanumberofsubstitutedphenols AT svetlanaaborovikova refinementofretentionindicesingaschromatographyforanumberofsubstitutedphenols AT dmitriydmatyushin refinementofretentionindicesingaschromatographyforanumberofsubstitutedphenols |