Nanolipoprotein particle (NLP) vaccine confers protection against Yersinia pestis aerosol challenge in a BALB/c mouse model

Nanolipoprotein particle (NLP) vaccine confers protection against Yersinia pestis aerosol challenge in a BALB/c mouse model

IntroductionYersinia pestis is the etiological agent of plague, a disease that remains a concern as demonstrated by recent outbreaks in Madagascar. Infection with Y. pestis results in a rapidly progressing illness that can only be successfully treated with antibiotics given shortly after symptom ons...

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Main Authors: Sergei S. Biryukov, Amy Rasley, Michael L. Davies, Christopher P. Klimko, Jennifer L. Dankmeyer, Melissa Hunter, Nathaniel O. Rill, Jennifer L. Shoe, Jeremy Miller, Yuli Talyansky, Barbara Sullinger, Matheo Herrera, Daniel Huang, Leslie Bautista, Lucy Pepe, Sandra K. G. Peters, Christian J. Xander, Elsie E. Martinez, Ronald G. Toothman, Kevin D. Mlynek, Joel A. Bozue, Ju Qiu, Nicholas O. Fischer, Christopher K. Cote
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
plague
Yersinia pestis
vaccine
nanolipoprotein particle
mice
pneumonic
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603710/full
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