The transcription factor PITX1 cooperates with super-enhancers to regulate the expression of DUSP4 and inhibit pyroptosis in pulmonary artery smooth muscle cells

The transcription factor PITX1 cooperates with super-enhancers to regulate the expression of DUSP4 and inhibit pyroptosis in pulmonary artery smooth muscle cells

Abstract Background Pulmonary hypertension (PH) is a highly fatal pathophysiological syndrome. The group 1 pulmonary arterial hypertension (PAH) is characterized by acute pulmonary vasoconstriction and chronic vascular remodeling caused by hyperplasia and hypertrophy of pulmonary artery smooth muscl...

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Bibliographic Details
Main Authors: Jingya Zhang, Yuyu Song, Xinru Wang, Xu Wang, Songyue Li, Xinyue Song, Chong Zhao, Jing Qi, Yunyun Tian, Baoshan Zhao, Xiaodong Zheng, Yan Xing
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Respiratory Research
Subjects:
Super-enhancer
PITX1
Pyroptosis
Pulmonary arterial hypertension
Online Access:https://doi.org/10.1186/s12931-025-03222-9
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