Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis.
<h4>Introduction</h4>Different Guided Tissue Regeneration (GTR) procedures, such as membranes, bone substitute materials, and Autologous Platelet Concentrates (APCs), have been applied after surgical root canal treatment (SRCT), which produce different outcomes. This study aimed to evalu...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0312751 |
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| author | Nader Muthanna Xiaoyue Guan Fouad Alzahrani Badr Sultan Saif Abdelrahman Seyam Ahmed Alsalman Ahmed Es Alajami Ang Li |
| author_facet | Nader Muthanna Xiaoyue Guan Fouad Alzahrani Badr Sultan Saif Abdelrahman Seyam Ahmed Alsalman Ahmed Es Alajami Ang Li |
| author_sort | Nader Muthanna |
| collection | DOAJ |
| description | <h4>Introduction</h4>Different Guided Tissue Regeneration (GTR) procedures, such as membranes, bone substitute materials, and Autologous Platelet Concentrates (APCs), have been applied after surgical root canal treatment (SRCT), which produce different outcomes. This study aimed to evaluate the impact of regenerative procedures on the healing process following SRCT.<h4>Methods</h4>A comprehensive search of PubMed, Embase, Scopus, Cochrane, and the Web of Science found Randomized Controlled Trials (RCTs) published until February 25, 2024. Manual searches were also conducted. Our main outcome was SRCT success or failure after GTR procedures. The Risk Ratio (RR) and failure rate meta-analysis used a fixed effects model with a 95% confidence interval (CI). Subgroup analyses were conducted based on the use of different GTR procedures for varying lesion types in SRCT.<h4>Results</h4>Out of 1,605 records, 16 studies with 690 lesions were included. Overall, GTR procedures significantly improved healing after SRCT in both 2D (RR: 0.50; 95% CI, 0.34-0.73; P < 0.001) and 3D evaluation methods (RR: 0.36; 95% CI, 0.15-0.90; P < 0.001) with no significant difference between the two methods.<h4>Conclusion</h4>GTR significantly improved SRCT healing regardless of the evaluation method used. Combining collagen membranes with bovine bone-derived hydroxyapatite significantly enhanced the healing process. Additionally, GTR procedures significantly improve healing in through-and-through lesions. |
| format | Article |
| id | doaj-art-bb83c4d0103148788cbb625acfde3797 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-bb83c4d0103148788cbb625acfde37972025-08-20T01:48:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031275110.1371/journal.pone.0312751Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis.Nader MuthannaXiaoyue GuanFouad AlzahraniBadr Sultan SaifAbdelrahman SeyamAhmed AlsalmanAhmed Es AlajamiAng Li<h4>Introduction</h4>Different Guided Tissue Regeneration (GTR) procedures, such as membranes, bone substitute materials, and Autologous Platelet Concentrates (APCs), have been applied after surgical root canal treatment (SRCT), which produce different outcomes. This study aimed to evaluate the impact of regenerative procedures on the healing process following SRCT.<h4>Methods</h4>A comprehensive search of PubMed, Embase, Scopus, Cochrane, and the Web of Science found Randomized Controlled Trials (RCTs) published until February 25, 2024. Manual searches were also conducted. Our main outcome was SRCT success or failure after GTR procedures. The Risk Ratio (RR) and failure rate meta-analysis used a fixed effects model with a 95% confidence interval (CI). Subgroup analyses were conducted based on the use of different GTR procedures for varying lesion types in SRCT.<h4>Results</h4>Out of 1,605 records, 16 studies with 690 lesions were included. Overall, GTR procedures significantly improved healing after SRCT in both 2D (RR: 0.50; 95% CI, 0.34-0.73; P < 0.001) and 3D evaluation methods (RR: 0.36; 95% CI, 0.15-0.90; P < 0.001) with no significant difference between the two methods.<h4>Conclusion</h4>GTR significantly improved SRCT healing regardless of the evaluation method used. Combining collagen membranes with bovine bone-derived hydroxyapatite significantly enhanced the healing process. Additionally, GTR procedures significantly improve healing in through-and-through lesions.https://doi.org/10.1371/journal.pone.0312751 |
| spellingShingle | Nader Muthanna Xiaoyue Guan Fouad Alzahrani Badr Sultan Saif Abdelrahman Seyam Ahmed Alsalman Ahmed Es Alajami Ang Li Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis. PLoS ONE |
| title | Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis. |
| title_full | Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis. |
| title_fullStr | Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis. |
| title_full_unstemmed | Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis. |
| title_short | Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis. |
| title_sort | impact of regenerative procedure on the healing process following surgical root canal treatment a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0312751 |
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