CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density
Abstract Objective Based on the available evidence, the cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing the stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed to examine the levels of CIRBP and HIF1α mRNA within breast tumor tissues and ex...
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| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-025-07265-5 |
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| author | Sajad Monjezi Vahid Soleimani Maryam Cheraghzadeh Saeed Ghanbari Maryam Adelipour |
| author_facet | Sajad Monjezi Vahid Soleimani Maryam Cheraghzadeh Saeed Ghanbari Maryam Adelipour |
| author_sort | Sajad Monjezi |
| collection | DOAJ |
| description | Abstract Objective Based on the available evidence, the cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing the stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed to examine the levels of CIRBP and HIF1α mRNA within breast tumor tissues and explore the relationship between their gene expression and tumor Microvascular density (MVD). Results The results revealed a significant upregulation of CIRBP (5.07-fold) and HIF1α (4.5-fold) gene expression in BC samples compared to the surrounding normal tissues (p < 0.001). This upregulation was also associated with various clinicopathologic features. Furthermore, there was a correlation between CIRBP mRNA expression, HIF1α mRNA expression, and MVD. Consequently, this study suggests that CIRBP may have a role in promoting angiogenesis in BC. |
| format | Article |
| id | doaj-art-bb828a57a186444e9869d1686bb7e50b |
| institution | OA Journals |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-bb828a57a186444e9869d1686bb7e50b2025-08-20T01:48:49ZengBMCBMC Research Notes1756-05002025-05-011811910.1186/s13104-025-07265-5CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular densitySajad Monjezi0Vahid Soleimani1Maryam Cheraghzadeh2Saeed Ghanbari3Maryam Adelipour4Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical SciencesDepartment of Pathology, School of Medicine, Cancer Institute, Tehran University of Medical ScienceDepartment of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical SciencesDepartment of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical SciencesDepartment of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical SciencesAbstract Objective Based on the available evidence, the cold-inducible RNA-binding protein (CIRBP) appears to play a role in increasing the stability of hypoxia-inducible factor 1-alpha (HIF1α) mRNA. This research aimed to examine the levels of CIRBP and HIF1α mRNA within breast tumor tissues and explore the relationship between their gene expression and tumor Microvascular density (MVD). Results The results revealed a significant upregulation of CIRBP (5.07-fold) and HIF1α (4.5-fold) gene expression in BC samples compared to the surrounding normal tissues (p < 0.001). This upregulation was also associated with various clinicopathologic features. Furthermore, there was a correlation between CIRBP mRNA expression, HIF1α mRNA expression, and MVD. Consequently, this study suggests that CIRBP may have a role in promoting angiogenesis in BC.https://doi.org/10.1186/s13104-025-07265-5Breast cancerMicrovascular densityGene expression |
| spellingShingle | Sajad Monjezi Vahid Soleimani Maryam Cheraghzadeh Saeed Ghanbari Maryam Adelipour CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density BMC Research Notes Breast cancer Microvascular density Gene expression |
| title | CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density |
| title_full | CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density |
| title_fullStr | CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density |
| title_full_unstemmed | CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density |
| title_short | CIRBP mRNA level in breast cancer is associated with HIF1α gene expression and microvascular density |
| title_sort | cirbp mrna level in breast cancer is associated with hif1α gene expression and microvascular density |
| topic | Breast cancer Microvascular density Gene expression |
| url | https://doi.org/10.1186/s13104-025-07265-5 |
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