Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients
This case series highlights four pediatric patients with coinfection of dengue fever and scrub typhus, presenting at Patan Hospital. Dengue fever is caused by flavivirus transmitted by Aedes mosquitoes, and scrub typhus is caused by Orientia tsutsugamushi transmitted by Leptotrombidium mites, which...
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| Format: | Article |
| Language: | English |
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Nepal Medical Association
2025-01-01
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| Series: | Journal of Nepal Medical Association |
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| Online Access: | https://www.jnma.com.np/jnma/index.php/jnma/article/view/8893 |
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| author | Sriram KC Bulbul Pradhan Inesh Khanal Aakripa Rani Shrestha |
| author_facet | Sriram KC Bulbul Pradhan Inesh Khanal Aakripa Rani Shrestha |
| author_sort | Sriram KC |
| collection | DOAJ |
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This case series highlights four pediatric patients with coinfection of dengue fever and scrub typhus, presenting at Patan Hospital. Dengue fever is caused by flavivirus transmitted by Aedes mosquitoes, and scrub typhus is caused by Orientia tsutsugamushi transmitted by Leptotrombidium mites, which share overlapping symptoms such as fever, headache, and abdominal pain, complicating the diagnosis. The cases were from different geographical regions of Nepal with varied presentation: from febrile illness to severe manifestations like meningoencephalitis and raised intracranial pressure. Two patients presented with hepatosplenomegaly, one with severe rash, and another with pneumonia-like symptoms. Laboratory findings confirmed coinfection, and management included IV antibiotics, antipyretics, and supportive management. Complications such as thrombocytopenia, transaminitis, and allergic reactions required interventions. This case series highlights the importance of early suspicion and treatment of coinfection to reduce prolonged hospitalization and prevent end-organ dysfunction, and mortality, especially in endemic regions.
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| format | Article |
| id | doaj-art-bb80b597df05422eafa93b45e477f9c5 |
| institution | Kabale University |
| issn | 0028-2715 1815-672X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nepal Medical Association |
| record_format | Article |
| series | Journal of Nepal Medical Association |
| spelling | doaj-art-bb80b597df05422eafa93b45e477f9c52025-02-04T09:26:15ZengNepal Medical AssociationJournal of Nepal Medical Association0028-27151815-672X2025-01-016328210.31729/jnma.8893Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric PatientsSriram KC0Bulbul Pradhan1Inesh Khanal2Aakripa Rani Shrestha3Department of Pediatrics, Patan Hospital, Patan Academy of Health Sciences, Lagankhel, Lalitpur, NepalDepartment of Pediatrics, Patan Hospital, Patan Academy of Health Sciences, Lagankhel, Lalitpur, NepalPatan Hospital, Patan Academy of Health Sciences, Lagankhel, Lalitpur, NepalPatan Hospital, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal This case series highlights four pediatric patients with coinfection of dengue fever and scrub typhus, presenting at Patan Hospital. Dengue fever is caused by flavivirus transmitted by Aedes mosquitoes, and scrub typhus is caused by Orientia tsutsugamushi transmitted by Leptotrombidium mites, which share overlapping symptoms such as fever, headache, and abdominal pain, complicating the diagnosis. The cases were from different geographical regions of Nepal with varied presentation: from febrile illness to severe manifestations like meningoencephalitis and raised intracranial pressure. Two patients presented with hepatosplenomegaly, one with severe rash, and another with pneumonia-like symptoms. Laboratory findings confirmed coinfection, and management included IV antibiotics, antipyretics, and supportive management. Complications such as thrombocytopenia, transaminitis, and allergic reactions required interventions. This case series highlights the importance of early suspicion and treatment of coinfection to reduce prolonged hospitalization and prevent end-organ dysfunction, and mortality, especially in endemic regions. https://www.jnma.com.np/jnma/index.php/jnma/article/view/8893co-infectiondengueNepalpediatricsscrub typhus |
| spellingShingle | Sriram KC Bulbul Pradhan Inesh Khanal Aakripa Rani Shrestha Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients Journal of Nepal Medical Association co-infection dengue Nepal pediatrics scrub typhus |
| title | Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients |
| title_full | Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients |
| title_fullStr | Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients |
| title_full_unstemmed | Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients |
| title_short | Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients |
| title_sort | dengue and scrub typhus co infection at a tertiary care centre in nepal a case series in pediatric patients |
| topic | co-infection dengue Nepal pediatrics scrub typhus |
| url | https://www.jnma.com.np/jnma/index.php/jnma/article/view/8893 |
| work_keys_str_mv | AT sriramkc dengueandscrubtyphuscoinfectionatatertiarycarecentreinnepalacaseseriesinpediatricpatients AT bulbulpradhan dengueandscrubtyphuscoinfectionatatertiarycarecentreinnepalacaseseriesinpediatricpatients AT ineshkhanal dengueandscrubtyphuscoinfectionatatertiarycarecentreinnepalacaseseriesinpediatricpatients AT aakriparanishrestha dengueandscrubtyphuscoinfectionatatertiarycarecentreinnepalacaseseriesinpediatricpatients |