Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients

This case series highlights four pediatric patients with coinfection of dengue fever and scrub typhus, presenting at Patan Hospital. Dengue fever is caused by flavivirus transmitted by Aedes mosquitoes, and scrub typhus is caused by Orientia tsutsugamushi transmitted by Leptotrombidium mites, which...

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Main Authors: Sriram KC, Bulbul Pradhan, Inesh Khanal, Aakripa Rani Shrestha
Format: Article
Language:English
Published: Nepal Medical Association 2025-01-01
Series:Journal of Nepal Medical Association
Subjects:
Online Access:https://www.jnma.com.np/jnma/index.php/jnma/article/view/8893
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author Sriram KC
Bulbul Pradhan
Inesh Khanal
Aakripa Rani Shrestha
author_facet Sriram KC
Bulbul Pradhan
Inesh Khanal
Aakripa Rani Shrestha
author_sort Sriram KC
collection DOAJ
description This case series highlights four pediatric patients with coinfection of dengue fever and scrub typhus, presenting at Patan Hospital. Dengue fever is caused by flavivirus transmitted by Aedes mosquitoes, and scrub typhus is caused by Orientia tsutsugamushi transmitted by Leptotrombidium mites, which share overlapping symptoms such as fever, headache, and abdominal pain, complicating the diagnosis. The cases were from different geographical regions of Nepal with varied presentation: from febrile illness to severe manifestations like meningoencephalitis and raised intracranial pressure. Two patients presented with hepatosplenomegaly, one with severe rash, and another with pneumonia-like symptoms. Laboratory findings confirmed coinfection, and management included IV antibiotics, antipyretics, and supportive management. Complications such as thrombocytopenia, transaminitis, and allergic reactions required interventions. This case series highlights the importance of early suspicion and treatment of coinfection to reduce prolonged hospitalization and prevent end-organ dysfunction, and mortality, especially in endemic regions.
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institution Kabale University
issn 0028-2715
1815-672X
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publishDate 2025-01-01
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spelling doaj-art-bb80b597df05422eafa93b45e477f9c52025-02-04T09:26:15ZengNepal Medical AssociationJournal of Nepal Medical Association0028-27151815-672X2025-01-016328210.31729/jnma.8893Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric PatientsSriram KC0Bulbul Pradhan1Inesh Khanal2Aakripa Rani Shrestha3Department of Pediatrics, Patan Hospital, Patan Academy of Health Sciences, Lagankhel, Lalitpur, NepalDepartment of Pediatrics, Patan Hospital, Patan Academy of Health Sciences, Lagankhel, Lalitpur, NepalPatan Hospital, Patan Academy of Health Sciences, Lagankhel, Lalitpur, NepalPatan Hospital, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal This case series highlights four pediatric patients with coinfection of dengue fever and scrub typhus, presenting at Patan Hospital. Dengue fever is caused by flavivirus transmitted by Aedes mosquitoes, and scrub typhus is caused by Orientia tsutsugamushi transmitted by Leptotrombidium mites, which share overlapping symptoms such as fever, headache, and abdominal pain, complicating the diagnosis. The cases were from different geographical regions of Nepal with varied presentation: from febrile illness to severe manifestations like meningoencephalitis and raised intracranial pressure. Two patients presented with hepatosplenomegaly, one with severe rash, and another with pneumonia-like symptoms. Laboratory findings confirmed coinfection, and management included IV antibiotics, antipyretics, and supportive management. Complications such as thrombocytopenia, transaminitis, and allergic reactions required interventions. This case series highlights the importance of early suspicion and treatment of coinfection to reduce prolonged hospitalization and prevent end-organ dysfunction, and mortality, especially in endemic regions. https://www.jnma.com.np/jnma/index.php/jnma/article/view/8893co-infectiondengueNepalpediatricsscrub typhus
spellingShingle Sriram KC
Bulbul Pradhan
Inesh Khanal
Aakripa Rani Shrestha
Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients
Journal of Nepal Medical Association
co-infection
dengue
Nepal
pediatrics
scrub typhus
title Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients
title_full Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients
title_fullStr Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients
title_full_unstemmed Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients
title_short Dengue and Scrub Typhus Co-infection at a Tertiary Care Centre in Nepal: A Case Series in Pediatric Patients
title_sort dengue and scrub typhus co infection at a tertiary care centre in nepal a case series in pediatric patients
topic co-infection
dengue
Nepal
pediatrics
scrub typhus
url https://www.jnma.com.np/jnma/index.php/jnma/article/view/8893
work_keys_str_mv AT sriramkc dengueandscrubtyphuscoinfectionatatertiarycarecentreinnepalacaseseriesinpediatricpatients
AT bulbulpradhan dengueandscrubtyphuscoinfectionatatertiarycarecentreinnepalacaseseriesinpediatricpatients
AT ineshkhanal dengueandscrubtyphuscoinfectionatatertiarycarecentreinnepalacaseseriesinpediatricpatients
AT aakriparanishrestha dengueandscrubtyphuscoinfectionatatertiarycarecentreinnepalacaseseriesinpediatricpatients