Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass Grafting
Background: Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases (CVD). However, little is known regarding the significance of elevated plasma MMP9 levels in patients during the long-term period following myocardial revascularisation. We...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/15/6/908 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849432534873538560 |
|---|---|
| author | Mikhail Popov Siarhei Dabravolski Vladislav Dontsov Sergei Vzvarov Evgeniy Agafonov Dmitriy Zybin Olga Radchenkova Dmitriy Saveliev Victoria Pronina Natalia Kashirina Liudmila Lipatova Mikhail Peklo Pavel Rutkevich Elena Yanushevskaya Alisa Sokolovskaya Arkadiy Metelkin Svetlana Verkhova Nikita Nikiforov Dmitriy Shumakov |
| author_facet | Mikhail Popov Siarhei Dabravolski Vladislav Dontsov Sergei Vzvarov Evgeniy Agafonov Dmitriy Zybin Olga Radchenkova Dmitriy Saveliev Victoria Pronina Natalia Kashirina Liudmila Lipatova Mikhail Peklo Pavel Rutkevich Elena Yanushevskaya Alisa Sokolovskaya Arkadiy Metelkin Svetlana Verkhova Nikita Nikiforov Dmitriy Shumakov |
| author_sort | Mikhail Popov |
| collection | DOAJ |
| description | Background: Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases (CVD). However, little is known regarding the significance of elevated plasma MMP9 levels in patients during the long-term period following myocardial revascularisation. We aimed to investigate the role of MMP9 in relation to myocardial status before and after myocardial revascularisation and to assess its long-term prognostic value. Methods: This prospective observational study included 200 male patients with ischaemic heart disease. All patients underwent direct myocardial revascularisation on a beating heart (off-pump surgery). Plasma MMP9 levels were analysed preoperatively, at 48 h postoperatively, and during the long-term follow-up period (one year postoperatively). Key echocardiographic parameters, specifically left ventricular ejection fraction (LVEF) and Left Ventricular End-Diastolic Volume (LVEDV), were also assessed. Results: MMP9 levels decreased significantly at 48 h postoperatively (<i>p</i> < 0.0001). During the long-term postoperative period, a clear relationship was demonstrated: higher 1-year MMP9 levels were associated with lower 1-year LVEF, whilst lower 1-year MMP9 levels were associated with higher 1-year LVEF. No significant correlation was observed between preoperative MMP9 levels and age or most other baseline laboratory parameters. Conclusions: Our study established an association between 1-year postoperative MMP9 levels and key parameters of left ventricular function during the long-term follow-up period. This suggests that MMP9 may serve as a novel biomarker for predicting outcomes following myocardial revascularisation. |
| format | Article |
| id | doaj-art-bb7b92f97235445f9f977dec183a1aa5 |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-bb7b92f97235445f9f977dec183a1aa52025-08-20T03:27:21ZengMDPI AGLife2075-17292025-06-0115690810.3390/life15060908Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass GraftingMikhail Popov0Siarhei Dabravolski1Vladislav Dontsov2Sergei Vzvarov3Evgeniy Agafonov4Dmitriy Zybin5Olga Radchenkova6Dmitriy Saveliev7Victoria Pronina8Natalia Kashirina9Liudmila Lipatova10Mikhail Peklo11Pavel Rutkevich12Elena Yanushevskaya13Alisa Sokolovskaya14Arkadiy Metelkin15Svetlana Verkhova16Nikita Nikiforov17Dmitriy Shumakov18M.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, RussiaDepartment of Biotechnology Engineering, Braude Academic College of Engineering, Snunit 51, P.O. Box 78, Karmiel 2161002, IsraelM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, RussiaM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, RussiaM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, RussiaM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, RussiaM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, RussiaM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, RussiaM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, RussiaNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, RussiaNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, RussiaNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, RussiaNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, RussiaNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, RussiaInstitute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, 125315 Moscow, RussiaInstitute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, 125315 Moscow, RussiaInstitute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, 125315 Moscow, RussiaInstitute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, 125315 Moscow, RussiaM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, RussiaBackground: Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases (CVD). However, little is known regarding the significance of elevated plasma MMP9 levels in patients during the long-term period following myocardial revascularisation. We aimed to investigate the role of MMP9 in relation to myocardial status before and after myocardial revascularisation and to assess its long-term prognostic value. Methods: This prospective observational study included 200 male patients with ischaemic heart disease. All patients underwent direct myocardial revascularisation on a beating heart (off-pump surgery). Plasma MMP9 levels were analysed preoperatively, at 48 h postoperatively, and during the long-term follow-up period (one year postoperatively). Key echocardiographic parameters, specifically left ventricular ejection fraction (LVEF) and Left Ventricular End-Diastolic Volume (LVEDV), were also assessed. Results: MMP9 levels decreased significantly at 48 h postoperatively (<i>p</i> < 0.0001). During the long-term postoperative period, a clear relationship was demonstrated: higher 1-year MMP9 levels were associated with lower 1-year LVEF, whilst lower 1-year MMP9 levels were associated with higher 1-year LVEF. No significant correlation was observed between preoperative MMP9 levels and age or most other baseline laboratory parameters. Conclusions: Our study established an association between 1-year postoperative MMP9 levels and key parameters of left ventricular function during the long-term follow-up period. This suggests that MMP9 may serve as a novel biomarker for predicting outcomes following myocardial revascularisation.https://www.mdpi.com/2075-1729/15/6/908ischaemic heart diseasematrix metalloproteinase 9 (MMP9)biomarkermyocardial revascularisation |
| spellingShingle | Mikhail Popov Siarhei Dabravolski Vladislav Dontsov Sergei Vzvarov Evgeniy Agafonov Dmitriy Zybin Olga Radchenkova Dmitriy Saveliev Victoria Pronina Natalia Kashirina Liudmila Lipatova Mikhail Peklo Pavel Rutkevich Elena Yanushevskaya Alisa Sokolovskaya Arkadiy Metelkin Svetlana Verkhova Nikita Nikiforov Dmitriy Shumakov Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass Grafting Life ischaemic heart disease matrix metalloproteinase 9 (MMP9) biomarker myocardial revascularisation |
| title | Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass Grafting |
| title_full | Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass Grafting |
| title_fullStr | Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass Grafting |
| title_full_unstemmed | Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass Grafting |
| title_short | Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass Grafting |
| title_sort | prognostic value of matrix metalloproteinase 9 mmp9 in patients following off pump coronary artery bypass grafting |
| topic | ischaemic heart disease matrix metalloproteinase 9 (MMP9) biomarker myocardial revascularisation |
| url | https://www.mdpi.com/2075-1729/15/6/908 |
| work_keys_str_mv | AT mikhailpopov prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT siarheidabravolski prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT vladislavdontsov prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT sergeivzvarov prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT evgeniyagafonov prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT dmitriyzybin prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT olgaradchenkova prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT dmitriysaveliev prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT victoriapronina prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT nataliakashirina prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT liudmilalipatova prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT mikhailpeklo prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT pavelrutkevich prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT elenayanushevskaya prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT alisasokolovskaya prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT arkadiymetelkin prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT svetlanaverkhova prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT nikitanikiforov prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting AT dmitriyshumakov prognosticvalueofmatrixmetalloproteinase9mmp9inpatientsfollowingoffpumpcoronaryarterybypassgrafting |