Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders
BackgroundDepressive disorders are highly prevalent among people with HIV (PWH) and are related to aberrant inflammation and immune responses. However, there is currently a lack of investigation into the neurological, inflammatory, endocrine, and immune aspects of HIV-associated depressive disorders...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1438085/full |
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| author | Yang Zhang Yang Zhang Yihui He Yihui He Yuan Fang Yuan Fang Miaotian Cai Guangqiang Sun Guangqiang Sun Rui Wang Rui Wang Jiaxin Zhen Jiaxin Zhen Yulin Zhang Zhen Li Zhen Li Yundong Ma Yundong Ma Tong Zhang Tong Zhang |
| author_facet | Yang Zhang Yang Zhang Yihui He Yihui He Yuan Fang Yuan Fang Miaotian Cai Guangqiang Sun Guangqiang Sun Rui Wang Rui Wang Jiaxin Zhen Jiaxin Zhen Yulin Zhang Zhen Li Zhen Li Yundong Ma Yundong Ma Tong Zhang Tong Zhang |
| author_sort | Yang Zhang |
| collection | DOAJ |
| description | BackgroundDepressive disorders are highly prevalent among people with HIV (PWH) and are related to aberrant inflammation and immune responses. However, there is currently a lack of investigation into the neurological, inflammatory, endocrine, and immune aspects of HIV-associated depressive disorders (HADD).MethodsThe study involved 33 HIV-positive men who have sex with men with depressive disorders (HADD group) and 47 without neuropsychiatric disorders (HIV control group). Participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans and assessments of peripheral blood. Peripheral blood cytokines, plasma concentrations of hormone and neurotrophic factors, and immune cell levels were determined using liquid chip, enzyme-linked immunosorbent assay, and flow cytometry, respectively. The correlation of imaging alterations with clinical variables and peripheral blood indicators was assessed.ResultsCompared to the HIV control group, the HADD group exhibited a higher fractional amplitude of low-frequency fluctuations in the left superior parietal gyrus, lower regional homogeneity in the left precentral gyrus, and reduced voxel-wise functional connectivity for the seed region in the right precentral gyrus with clusters in the right cuneus, etc. Furthermore, the HADD group had higher levels of interferon-gamma, a higher frequency of non-classical monocytes, and higher expression levels of perforin and CD38 on specific cells. These imaging results were significantly correlated with peripheral blood indicators and clinical variables.ConclusionThis rs-fMRI study provides considerable evidence for abnormal intrinsic brain activity in people with HADD. Furthermore, our data also indicate the detrimental effects of depression-related inflammation on PWH. Therefore, it is imperative to increase attention to HADD and implement effective preventive interventions accordingly. |
| format | Article |
| id | doaj-art-bb79d43cbc7e494e84f6f61224a592f1 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-bb79d43cbc7e494e84f6f61224a592f12025-01-20T07:20:20ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.14380851438085Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disordersYang Zhang0Yang Zhang1Yihui He2Yihui He3Yuan Fang4Yuan Fang5Miaotian Cai6Guangqiang Sun7Guangqiang Sun8Rui Wang9Rui Wang10Jiaxin Zhen11Jiaxin Zhen12Yulin Zhang13Zhen Li14Zhen Li15Yundong Ma16Yundong Ma17Tong Zhang18Tong Zhang19Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Sexually Transmitted Disease Control, Beijing, ChinaPostgraduate Union Training Base of Jinzhou Medical University, PLA Rocket Force Characteristic Medical Center, Beijing, ChinaDepartment of Neurology, PLA Rocket Force Characteristic Medical Center, Beijing, ChinaCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Sexually Transmitted Disease Control, Beijing, ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Sexually Transmitted Disease Control, Beijing, ChinaCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Sexually Transmitted Disease Control, Beijing, ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of HIV/AIDS Research, Beijing, ChinaBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaAdvanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, ChinaCenter for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Sexually Transmitted Disease Control, Beijing, ChinaBackgroundDepressive disorders are highly prevalent among people with HIV (PWH) and are related to aberrant inflammation and immune responses. However, there is currently a lack of investigation into the neurological, inflammatory, endocrine, and immune aspects of HIV-associated depressive disorders (HADD).MethodsThe study involved 33 HIV-positive men who have sex with men with depressive disorders (HADD group) and 47 without neuropsychiatric disorders (HIV control group). Participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans and assessments of peripheral blood. Peripheral blood cytokines, plasma concentrations of hormone and neurotrophic factors, and immune cell levels were determined using liquid chip, enzyme-linked immunosorbent assay, and flow cytometry, respectively. The correlation of imaging alterations with clinical variables and peripheral blood indicators was assessed.ResultsCompared to the HIV control group, the HADD group exhibited a higher fractional amplitude of low-frequency fluctuations in the left superior parietal gyrus, lower regional homogeneity in the left precentral gyrus, and reduced voxel-wise functional connectivity for the seed region in the right precentral gyrus with clusters in the right cuneus, etc. Furthermore, the HADD group had higher levels of interferon-gamma, a higher frequency of non-classical monocytes, and higher expression levels of perforin and CD38 on specific cells. These imaging results were significantly correlated with peripheral blood indicators and clinical variables.ConclusionThis rs-fMRI study provides considerable evidence for abnormal intrinsic brain activity in people with HADD. Furthermore, our data also indicate the detrimental effects of depression-related inflammation on PWH. Therefore, it is imperative to increase attention to HADD and implement effective preventive interventions accordingly.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1438085/fullhuman immunodeficiency virusdepressive disordersresting-state functional magnetic resonance imagingperipheral immunityinflammation |
| spellingShingle | Yang Zhang Yang Zhang Yihui He Yihui He Yuan Fang Yuan Fang Miaotian Cai Guangqiang Sun Guangqiang Sun Rui Wang Rui Wang Jiaxin Zhen Jiaxin Zhen Yulin Zhang Zhen Li Zhen Li Yundong Ma Yundong Ma Tong Zhang Tong Zhang Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders Frontiers in Psychiatry human immunodeficiency virus depressive disorders resting-state functional magnetic resonance imaging peripheral immunity inflammation |
| title | Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders |
| title_full | Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders |
| title_fullStr | Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders |
| title_full_unstemmed | Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders |
| title_short | Brain function abnormalities and inflammation in HIV-positive men who have sex with men with depressive disorders |
| title_sort | brain function abnormalities and inflammation in hiv positive men who have sex with men with depressive disorders |
| topic | human immunodeficiency virus depressive disorders resting-state functional magnetic resonance imaging peripheral immunity inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1438085/full |
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