Determining Hepatitis B Serology After Immune Prophylaxis in Babies of Hepatitis B Surface Antigen Positive Mothers
Objective: This study aims to evaluate the post-immunization hepatitis B serology of babies born to hepatitis B surface antigen (HBsAg) positive mothers, and to investigate the relationship of antiHBs titer with maternal age, delivery type and baby’s weight, week of gestation, breast milk intake and...
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Istanbul University Press
2021-09-01
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| Series: | Çocuk Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9E46BD9F845240BC8BA5BAFB0D4C9CCE |
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| author | Emine Tekin Müferet Ergüven Öznur Yılmaz Gondal |
| author_facet | Emine Tekin Müferet Ergüven Öznur Yılmaz Gondal |
| author_sort | Emine Tekin |
| collection | DOAJ |
| description | Objective: This study aims to evaluate the post-immunization hepatitis B serology of babies born to hepatitis B surface antigen (HBsAg) positive mothers, and to investigate the relationship of antiHBs titer with maternal age, delivery type and baby’s weight, week of gestation, breast milk intake and cigarette exposure. Material and Method: Babies born from HBsAg positive mothers admitted to the Ministry of Health Göztepe Training and Research Hospital Gynecology Clinic were included. Recombinant hepatitis B Immunoglobulin (HBIG) and vaccine were administered intramuscularly to all babies within the first 24 hours. Babies were vaccinated according to the 0, 1, 6 month scheme, and their serum HBsAg and anti-HBs levels were measured when they were 9-12 months old. Maternal age, delivery type, birth weight, gestational week, breast milk intake and smoking exposure were questioned and recorded. Results: Fifty babies were included, 26 (52%) of them were girls and 24 (48%) were boys. HBsAg was found positive in one baby whose mother was also positive for Hepatitis B e antigen (HBeAg). Except for six babies, protective anti-HBs positivity (88%) was detected. Anti-HBs titers were found to be significantly lower in babies with a gestational age of <37 weeks (preterm) (p=0.014). The mean anti-HBs levels were higher in male babies, born by normal vaginal delivery, birth weight> 2500 grams, breastfed less than 6 months, and not exposed to smoking, but this difference was not statistically significant. No relationship was found with maternal age. Conclusion: Hepatitis B serology should be screened in all pregnant women, necessary counseling should be given to those who are positive for HBsAg, babies should be immunized effectively, 4 doses of vaccination should be given to premature babies and the vaccine response should be checked. Vaccination is the most important method of protection against hepatitis B. |
| format | Article |
| id | doaj-art-bb74dcc34e42473a9cfb6e902e53714a |
| institution | OA Journals |
| issn | 1308-8491 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | Çocuk Dergisi |
| spelling | doaj-art-bb74dcc34e42473a9cfb6e902e53714a2025-08-20T02:15:19ZengIstanbul University PressÇocuk Dergisi1308-84912021-09-012129910410.26650/jchild.2021.799869123456Determining Hepatitis B Serology After Immune Prophylaxis in Babies of Hepatitis B Surface Antigen Positive MothersEmine Tekin0https://orcid.org/0000-0002-5115-8890Müferet Ergüven1https://orcid.org/0000-0002-3255-1208Öznur Yılmaz Gondal2https://orcid.org/0000-0003-3983-0557Giresun Üniversitesi, Giresun, TurkiyeDüzce Üniversitesi, Duzce, TurkiyeBeykent Üniversitesi, Istanbul, TurkiyeObjective: This study aims to evaluate the post-immunization hepatitis B serology of babies born to hepatitis B surface antigen (HBsAg) positive mothers, and to investigate the relationship of antiHBs titer with maternal age, delivery type and baby’s weight, week of gestation, breast milk intake and cigarette exposure. Material and Method: Babies born from HBsAg positive mothers admitted to the Ministry of Health Göztepe Training and Research Hospital Gynecology Clinic were included. Recombinant hepatitis B Immunoglobulin (HBIG) and vaccine were administered intramuscularly to all babies within the first 24 hours. Babies were vaccinated according to the 0, 1, 6 month scheme, and their serum HBsAg and anti-HBs levels were measured when they were 9-12 months old. Maternal age, delivery type, birth weight, gestational week, breast milk intake and smoking exposure were questioned and recorded. Results: Fifty babies were included, 26 (52%) of them were girls and 24 (48%) were boys. HBsAg was found positive in one baby whose mother was also positive for Hepatitis B e antigen (HBeAg). Except for six babies, protective anti-HBs positivity (88%) was detected. Anti-HBs titers were found to be significantly lower in babies with a gestational age of <37 weeks (preterm) (p=0.014). The mean anti-HBs levels were higher in male babies, born by normal vaginal delivery, birth weight> 2500 grams, breastfed less than 6 months, and not exposed to smoking, but this difference was not statistically significant. No relationship was found with maternal age. Conclusion: Hepatitis B serology should be screened in all pregnant women, necessary counseling should be given to those who are positive for HBsAg, babies should be immunized effectively, 4 doses of vaccination should be given to premature babies and the vaccine response should be checked. Vaccination is the most important method of protection against hepatitis B.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9E46BD9F845240BC8BA5BAFB0D4C9CCEanti-hbshepatitis bimmunoprophylaxisperinatal transmissionvaccine |
| spellingShingle | Emine Tekin Müferet Ergüven Öznur Yılmaz Gondal Determining Hepatitis B Serology After Immune Prophylaxis in Babies of Hepatitis B Surface Antigen Positive Mothers Çocuk Dergisi anti-hbs hepatitis b immunoprophylaxis perinatal transmission vaccine |
| title | Determining Hepatitis B Serology After Immune Prophylaxis in Babies of Hepatitis B Surface Antigen Positive Mothers |
| title_full | Determining Hepatitis B Serology After Immune Prophylaxis in Babies of Hepatitis B Surface Antigen Positive Mothers |
| title_fullStr | Determining Hepatitis B Serology After Immune Prophylaxis in Babies of Hepatitis B Surface Antigen Positive Mothers |
| title_full_unstemmed | Determining Hepatitis B Serology After Immune Prophylaxis in Babies of Hepatitis B Surface Antigen Positive Mothers |
| title_short | Determining Hepatitis B Serology After Immune Prophylaxis in Babies of Hepatitis B Surface Antigen Positive Mothers |
| title_sort | determining hepatitis b serology after immune prophylaxis in babies of hepatitis b surface antigen positive mothers |
| topic | anti-hbs hepatitis b immunoprophylaxis perinatal transmission vaccine |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/9E46BD9F845240BC8BA5BAFB0D4C9CCE |
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