Genetic correction of serum AFP level improves risk prediction of primary hepatocellular carcinoma in the Dongfeng–Tongji cohort study
Abstract Serum alpha‐fetoprotein (AFP) is the most commonly used tumor biomarker for screening and diagnosis of primary hepatocellular carcinoma (HCC). However, the predictive effect for HCC risk is still unsatisfactory. The aim of this prospective study was to estimate whether the individual geneti...
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| Format: | Article |
| Language: | English |
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Wiley
2018-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1481 |
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| author | Ke Wang Yansen Bai Shi Chen Jiao Huang Jing Yuan Weihong Chen Ping Yao Xiaoping Miao Youjie Wang Yuan Liang Xiaomin Zhang Meian He Handong Yang Huan Guo Sheng Wei |
| author_facet | Ke Wang Yansen Bai Shi Chen Jiao Huang Jing Yuan Weihong Chen Ping Yao Xiaoping Miao Youjie Wang Yuan Liang Xiaomin Zhang Meian He Handong Yang Huan Guo Sheng Wei |
| author_sort | Ke Wang |
| collection | DOAJ |
| description | Abstract Serum alpha‐fetoprotein (AFP) is the most commonly used tumor biomarker for screening and diagnosis of primary hepatocellular carcinoma (HCC). However, the predictive effect for HCC risk is still unsatisfactory. The aim of this prospective study was to estimate whether the individual genetic correction could improve the prediction efficiency of AFP for HCC risk. A prospective analysis with 9819 baseline HCC‐free individuals based on a large population‐based Chinese cohort study was performed. Two single‐nucleotide polymorphisms (SNPs) associated with serum AFP level were used to calculate the genetic corrected AFP level (rs12506899 and rs2251844). Statistical analysis including logistic regression analysis and the area under the receiver operating characteristic (ROC) curve were used to assess the discriminative ability of the original and genetic corrected AFP level for HCC risk. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were presented. Fifty‐seven participants were diagnosed with HCC for the first time. After adjusting AFP level with genetic effects, the participants for HCC risk increased compared to those with AFP level alone (OR = 5.34, 95% CI = 2.57–11.13; P < 0.001 vs. OR = 5.04, 95% CI = 2.46–10.30; P < 0.001). In addition, the area under the curve (AUC) for the discrimination of HCC elevated from 0.611 to 0.726. The efficiency in HCC prediction using serum AFP level can be improved by adjusting AFP level based on genetic effects. The genetic correction effect on serum AFP should be considered in the clinic application of such tumor biomarkers. |
| format | Article |
| id | doaj-art-bb734571aa0d4c809565e5d8ea99bcc2 |
| institution | OA Journals |
| issn | 2045-7634 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-bb734571aa0d4c809565e5d8ea99bcc22025-08-20T02:38:18ZengWileyCancer Medicine2045-76342018-06-01762691269810.1002/cam4.1481Genetic correction of serum AFP level improves risk prediction of primary hepatocellular carcinoma in the Dongfeng–Tongji cohort studyKe Wang0Yansen Bai1Shi Chen2Jiao Huang3Jing Yuan4Weihong Chen5Ping Yao6Xiaoping Miao7Youjie Wang8Yuan Liang9Xiaomin Zhang10Meian He11Handong Yang12Huan Guo13Sheng Wei14Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Occupational and Environmental Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Occupational and Environmental Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Occupational and Environmental Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Maternal and Child Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Social Medicine and Health Management School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Occupational and Environmental Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Occupational and Environmental Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDongfeng Central Hospital Dongfeng Motor Corporation and Hubei University of Medicine Shiyan Hubei ChinaDepartment of Occupational and Environmental Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaAbstract Serum alpha‐fetoprotein (AFP) is the most commonly used tumor biomarker for screening and diagnosis of primary hepatocellular carcinoma (HCC). However, the predictive effect for HCC risk is still unsatisfactory. The aim of this prospective study was to estimate whether the individual genetic correction could improve the prediction efficiency of AFP for HCC risk. A prospective analysis with 9819 baseline HCC‐free individuals based on a large population‐based Chinese cohort study was performed. Two single‐nucleotide polymorphisms (SNPs) associated with serum AFP level were used to calculate the genetic corrected AFP level (rs12506899 and rs2251844). Statistical analysis including logistic regression analysis and the area under the receiver operating characteristic (ROC) curve were used to assess the discriminative ability of the original and genetic corrected AFP level for HCC risk. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were presented. Fifty‐seven participants were diagnosed with HCC for the first time. After adjusting AFP level with genetic effects, the participants for HCC risk increased compared to those with AFP level alone (OR = 5.34, 95% CI = 2.57–11.13; P < 0.001 vs. OR = 5.04, 95% CI = 2.46–10.30; P < 0.001). In addition, the area under the curve (AUC) for the discrimination of HCC elevated from 0.611 to 0.726. The efficiency in HCC prediction using serum AFP level can be improved by adjusting AFP level based on genetic effects. The genetic correction effect on serum AFP should be considered in the clinic application of such tumor biomarkers.https://doi.org/10.1002/cam4.1481Alpha‐fetoproteingenetic correctionprediction efficiencyprimary hepatocellular carcinomasingle‐nucleotide polymorphisms |
| spellingShingle | Ke Wang Yansen Bai Shi Chen Jiao Huang Jing Yuan Weihong Chen Ping Yao Xiaoping Miao Youjie Wang Yuan Liang Xiaomin Zhang Meian He Handong Yang Huan Guo Sheng Wei Genetic correction of serum AFP level improves risk prediction of primary hepatocellular carcinoma in the Dongfeng–Tongji cohort study Cancer Medicine Alpha‐fetoprotein genetic correction prediction efficiency primary hepatocellular carcinoma single‐nucleotide polymorphisms |
| title | Genetic correction of serum AFP level improves risk prediction of primary hepatocellular carcinoma in the Dongfeng–Tongji cohort study |
| title_full | Genetic correction of serum AFP level improves risk prediction of primary hepatocellular carcinoma in the Dongfeng–Tongji cohort study |
| title_fullStr | Genetic correction of serum AFP level improves risk prediction of primary hepatocellular carcinoma in the Dongfeng–Tongji cohort study |
| title_full_unstemmed | Genetic correction of serum AFP level improves risk prediction of primary hepatocellular carcinoma in the Dongfeng–Tongji cohort study |
| title_short | Genetic correction of serum AFP level improves risk prediction of primary hepatocellular carcinoma in the Dongfeng–Tongji cohort study |
| title_sort | genetic correction of serum afp level improves risk prediction of primary hepatocellular carcinoma in the dongfeng tongji cohort study |
| topic | Alpha‐fetoprotein genetic correction prediction efficiency primary hepatocellular carcinoma single‐nucleotide polymorphisms |
| url | https://doi.org/10.1002/cam4.1481 |
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