STMN1–IGFBP5 axis induces senescence and extracellular matrix degradation in nucleus pulposus cells: In vivo and in vitro insights

STMN1–IGFBP5 axis induces senescence and extracellular matrix degradation in nucleus pulposus cells: In vivo and in vitro insights

Abstract Cellular dysfunction induced by senescent nucleus pulposus (NP) cells is a key factor in the pathogenesis of intervertebral disc degeneration (IDD). Stathmin 1 (STMN1) has been proposed as a telomere-associated senescence marker implicated in senescence in many age-related diseases. Neverth...

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Bibliographic Details
Main Authors: Lei Li, Guangzhi Zhang, Zhili Yang, Zhenyu Cao, Dongxin Wang, Xuewen Kang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
STMN1
IGFBP5
Nucleus pulposus
Senescence
Extracellular matrix degradation
Online Access:https://doi.org/10.1186/s10020-025-01220-7
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