Pemphigus herpetiformis : A rare clinical variant of pemphigus
Pemphigus herpetiformis is an autoimmune blistering disease. We report a case of pemphigus herpetiformis, a generalized form, manifested as pruritic grouped vesicles at extremities and trunk, in a seventy years old man. Neutrophil dominant inflammatory substrate was seen in histopathology. Direct i...
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Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
2016-01-01
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| Series: | Nepal Journal of Dermatology, Venereology & Leprology |
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| Online Access: | https://nepjol.info/index.php/NJDVL/article/view/14308 |
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| author | P Shrestha R B Tajhya A Pokharel |
| author_facet | P Shrestha R B Tajhya A Pokharel |
| author_sort | P Shrestha |
| collection | DOAJ |
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Pemphigus herpetiformis is an autoimmune blistering disease. We report a case of pemphigus herpetiformis, a generalized form, manifested as pruritic grouped vesicles at extremities and trunk, in a seventy years old man. Neutrophil dominant inflammatory substrate was seen in histopathology. Direct immunofluorescene revealed IgG reactivity in net like pattern at upper epidermis, confirming pemphigus. The patient responded well to prednisolone and colchicine combination initially and maintained remission later on colchicine alone. Colchicine has anti-mitotic, anti-inflammatory and immunosuppressive mechanism of actions and proven benefits in neutrophilic dermatoses. Therefore we recommend colchicine as mono therapy or in combination with immunosuppressive, for the treatment of pemphigus herpetiformis where neutrophil is predominant inflammatory infiltrate histologically.
NJDVL Vol. 13, No. 1, 2015 Page: 61-65
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| format | Article |
| id | doaj-art-bb707d5c29644e09b49949a9df0eb257 |
| institution | Kabale University |
| issn | 2091-0231 2091-167X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) |
| record_format | Article |
| series | Nepal Journal of Dermatology, Venereology & Leprology |
| spelling | doaj-art-bb707d5c29644e09b49949a9df0eb2572025-08-24T10:06:38ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2016-01-01131Pemphigus herpetiformis : A rare clinical variant of pemphigusP Shrestha0R B Tajhya1A Pokharel2Department of Dermatology, Vayodha Hospital Pvt. Ltd, Balkhu, KathmanduDepartment of Dermatology, Vayodha Hospital Pvt. Ltd, Balkhu, KathmanduDepartment of Dermatology, Chitwan Medical College, Bharatpur Pemphigus herpetiformis is an autoimmune blistering disease. We report a case of pemphigus herpetiformis, a generalized form, manifested as pruritic grouped vesicles at extremities and trunk, in a seventy years old man. Neutrophil dominant inflammatory substrate was seen in histopathology. Direct immunofluorescene revealed IgG reactivity in net like pattern at upper epidermis, confirming pemphigus. The patient responded well to prednisolone and colchicine combination initially and maintained remission later on colchicine alone. Colchicine has anti-mitotic, anti-inflammatory and immunosuppressive mechanism of actions and proven benefits in neutrophilic dermatoses. Therefore we recommend colchicine as mono therapy or in combination with immunosuppressive, for the treatment of pemphigus herpetiformis where neutrophil is predominant inflammatory infiltrate histologically. NJDVL Vol. 13, No. 1, 2015 Page: 61-65 https://nepjol.info/index.php/NJDVL/article/view/14308PemphigusHerpetiformPruriticVesicles |
| spellingShingle | P Shrestha R B Tajhya A Pokharel Pemphigus herpetiformis : A rare clinical variant of pemphigus Nepal Journal of Dermatology, Venereology & Leprology Pemphigus Herpetiform Pruritic Vesicles |
| title | Pemphigus herpetiformis : A rare clinical variant of pemphigus |
| title_full | Pemphigus herpetiformis : A rare clinical variant of pemphigus |
| title_fullStr | Pemphigus herpetiformis : A rare clinical variant of pemphigus |
| title_full_unstemmed | Pemphigus herpetiformis : A rare clinical variant of pemphigus |
| title_short | Pemphigus herpetiformis : A rare clinical variant of pemphigus |
| title_sort | pemphigus herpetiformis a rare clinical variant of pemphigus |
| topic | Pemphigus Herpetiform Pruritic Vesicles |
| url | https://nepjol.info/index.php/NJDVL/article/view/14308 |
| work_keys_str_mv | AT pshrestha pemphigusherpetiformisarareclinicalvariantofpemphigus AT rbtajhya pemphigusherpetiformisarareclinicalvariantofpemphigus AT apokharel pemphigusherpetiformisarareclinicalvariantofpemphigus |