Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease
Introduction: Fibroblasts are stromal and connective tissue cells that play crucial roles in the intracellular matrix and granulation tissue synthesis during tissue proliferation. They are also responsible for epithelialization and healing of skin lesions. Aim: Our aim was to compare the use of a...
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Medycyna Praktyczna
2025-07-01
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| Series: | Videosurgery and Other Miniinvasive Techniques |
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| Online Access: | http://mp.pl/videosurgery/issue/article/17959/ |
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| author | Bazylbek Zhakiyev Didar Khassenov Gulnara Sakhipova Natalya Zagorulya Gaukhar Kuanyshbayeva Nurlan Zhampeissov Damir Biktashev Murat Jakanov Ainur Donayeva Ibrahim A. Abdelazim |
| author_facet | Bazylbek Zhakiyev Didar Khassenov Gulnara Sakhipova Natalya Zagorulya Gaukhar Kuanyshbayeva Nurlan Zhampeissov Damir Biktashev Murat Jakanov Ainur Donayeva Ibrahim A. Abdelazim |
| author_sort | Bazylbek Zhakiyev |
| collection | DOAJ |
| description | Introduction: Fibroblasts are stromal and connective tissue cells that play crucial roles in the intracellular matrix and granulation tissue synthesis during tissue proliferation. They are also responsible for epithelialization and healing of skin lesions.
Aim: Our aim was to compare the use of allogeneic fibroblasts with conventional debridement after successful endovascular interventions (EVIs) for the treatment of chronic ulcers induced by peripheral artery disease (PAD).
Materials and Methods: A total of 116 participants with chronic ulcers due to PAD were randomly assigned, after successful EVI, to receive either allogeneic fibroblasts (study group; n = 58) or conventional debridement (control group; n = 58) for treatment of the ulcers. The participant data were collected over 1 year of follow-up to compare the effectiveness of both methods.
Results: The mean (SD) duration of initial and complete healing of chronic ulcers after successful EVI was shorter in the allogeneic fibroblast group (2.59 [0.53] and 5.04 [0.58] months, respectively) than in the controls (3.56 [0.44] and 5.8 [0.35] months, respectively; P <0.001 for all). A correlation analysis showed a moderately significant correlation between the healing of chronic ulcers (both initial and complete) after successful EVI and the use of allogeneic fibroblasts.
Conclusions: Allogeneic fibroblasts are an effective and noninvasive option for the treatment of chronic PAD-induced ulcers after successful EVI. The duration of initial and complete healing was significantly shorter in the allogeneic fibroblast group than in the conventional debridement group. |
| format | Article |
| id | doaj-art-bb6eb025c791459d989b8da1d410b78e |
| institution | DOAJ |
| issn | 1895-4588 2299-0054 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Medycyna Praktyczna |
| record_format | Article |
| series | Videosurgery and Other Miniinvasive Techniques |
| spelling | doaj-art-bb6eb025c791459d989b8da1d410b78e2025-08-20T02:50:04ZengMedycyna PraktycznaVideosurgery and Other Miniinvasive Techniques1895-45882299-00542025-07-012022523310.20452/wiitm.2025.17959Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery diseaseBazylbek Zhakiyev0 Didar Khassenov1Gulnara Sakhipova2Natalya Zagorulya3Gaukhar Kuanyshbayeva4Nurlan Zhampeissov5Damir Biktashev6Murat Jakanov7Ainur Donayeva8Ibrahim A. Abdelazim9Department of Surgical Diseases No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, KazakhstanDepartment of Interventional Radiology, National Research Oncology Center, Astana, KazakhstanDepartment of General Medicine, West Kazakhstan Marat Ospanov Medical University, Aktobe, KazakhstanDepartment of Internal Diseases and Geriatrics, Astana Medical University, Astana, KazakhstanDepartment of Fundamentals of Medicine, Astana Medical University, Astana, KazakhstanDepartment of Radiation Diagnostics and Ultrasound Imaging, National Scientific Medical Centre, Astana, KazakhstanDepartment of Internal Diseases, Gastroenterology, Endocrinology and Pulmonology, Astana Medical University, Astana, KazakhstanDepartment of General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, KazakhstanDepartment of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, KazakhstanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, EgyptIntroduction: Fibroblasts are stromal and connective tissue cells that play crucial roles in the intracellular matrix and granulation tissue synthesis during tissue proliferation. They are also responsible for epithelialization and healing of skin lesions. Aim: Our aim was to compare the use of allogeneic fibroblasts with conventional debridement after successful endovascular interventions (EVIs) for the treatment of chronic ulcers induced by peripheral artery disease (PAD). Materials and Methods: A total of 116 participants with chronic ulcers due to PAD were randomly assigned, after successful EVI, to receive either allogeneic fibroblasts (study group; n = 58) or conventional debridement (control group; n = 58) for treatment of the ulcers. The participant data were collected over 1 year of follow-up to compare the effectiveness of both methods. Results: The mean (SD) duration of initial and complete healing of chronic ulcers after successful EVI was shorter in the allogeneic fibroblast group (2.59 [0.53] and 5.04 [0.58] months, respectively) than in the controls (3.56 [0.44] and 5.8 [0.35] months, respectively; P <0.001 for all). A correlation analysis showed a moderately significant correlation between the healing of chronic ulcers (both initial and complete) after successful EVI and the use of allogeneic fibroblasts. Conclusions: Allogeneic fibroblasts are an effective and noninvasive option for the treatment of chronic PAD-induced ulcers after successful EVI. The duration of initial and complete healing was significantly shorter in the allogeneic fibroblast group than in the conventional debridement group.http://mp.pl/videosurgery/issue/article/17959/allogeneic fibroblastschronic ulcerscon‑ ventional debride‑ mentendovascular interventionsperiph‑ eral artery disease |
| spellingShingle | Bazylbek Zhakiyev Didar Khassenov Gulnara Sakhipova Natalya Zagorulya Gaukhar Kuanyshbayeva Nurlan Zhampeissov Damir Biktashev Murat Jakanov Ainur Donayeva Ibrahim A. Abdelazim Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease Videosurgery and Other Miniinvasive Techniques allogeneic fibroblasts chronic ulcers con‑ ventional debride‑ ment endovascular interventions periph‑ eral artery disease |
| title | Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease |
| title_full | Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease |
| title_fullStr | Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease |
| title_full_unstemmed | Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease |
| title_short | Allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease |
| title_sort | allogeneic fibroblasts vs conventional debridement after successful endovascular interventions for treating chronic ulcers induced by peripheral artery disease |
| topic | allogeneic fibroblasts chronic ulcers con‑ ventional debride‑ ment endovascular interventions periph‑ eral artery disease |
| url | http://mp.pl/videosurgery/issue/article/17959/ |
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