Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19
Abstract We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention a...
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Nature Portfolio
2024-09-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-66267-8 |
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| author | Huan Wang Liyuan Tao Liyan Cui Yahong Chen Dongyang Liu Lixiang Xue Yuping Yang Yang Lv Fuchun Zhang Tiancheng Wang Xiaoxiao Wang Wanqiong Yuan Hao Liu Jie Huang Yanfang Jiang Na Liu Lijuan Yang Yunjing Hu Yanfang Li Yuling Gao Haiyan Li Baohua Li Chunli Song |
| author_facet | Huan Wang Liyuan Tao Liyan Cui Yahong Chen Dongyang Liu Lixiang Xue Yuping Yang Yang Lv Fuchun Zhang Tiancheng Wang Xiaoxiao Wang Wanqiong Yuan Hao Liu Jie Huang Yanfang Jiang Na Liu Lijuan Yang Yunjing Hu Yanfang Li Yuling Gao Haiyan Li Baohua Li Chunli Song |
| author_sort | Huan Wang |
| collection | DOAJ |
| description | Abstract We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1. Subjects recorded PCR or antigen tests and the symptoms of COVID-19 twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines were measured. The rates of COVID-19 infection were 50.5% in the vitamin D2 group and 52.4% in the non-intervention group (P = 0.785). There was no difference in the COVID-19 symptoms between the two groups. The mean 25(OH)D level significantly increased from 14.1 to 31.1 ng/mL after administration (P < 0.001). The difference between the two groups was not significant for the concentrations of CRP, C1q and inflammatory cytokines on the thirtieth day of the trial. According to the second level of vitamin D, there was a 14.3% difference in positive infection rates between the vitamin D adequate (> 30 ng/mL) and deficient groups (< 20 ng/mL). Adequate vitamin D had a tendency to prevent COVID-19. Trial registration: ClinicalTrials.gov NCT05673980, dated: 12/2022. |
| format | Article |
| id | doaj-art-bb6cd034993348ada0a1632c53a930c1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-bb6cd034993348ada0a1632c53a930c12025-01-05T12:29:07ZengNature PortfolioScientific Reports2045-23222024-09-011411910.1038/s41598-024-66267-8Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19Huan Wang0Liyuan Tao1Liyan Cui2Yahong Chen3Dongyang Liu4Lixiang Xue5Yuping Yang6Yang Lv7Fuchun Zhang8Tiancheng Wang9Xiaoxiao Wang10Wanqiong Yuan11Hao Liu12Jie Huang13Yanfang Jiang14Na Liu15Lijuan Yang16Yunjing Hu17Yanfang Li18Yuling Gao19Haiyan Li20Baohua Li21Chunli Song22Department of Orthopedics, Peking University Third HospitalResearch Center of Clinical Epidemiology, Peking University Third HospitalDepartment of Clinical Laboratory, Peking University Third HospitalDepartment of Pulmonary and Critical Care Medicine, Peking University Third HospitalDrug Clinical Trial Center, Peking University Third HospitalCenter of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third HospitalInstitute of Sports Medicine, Peking University Third HospitalOrthopedic Trauma, Peking University Third HospitalBeijing Haidian HospitalDepartment of Clinical Laboratory, Peking University Third HospitalResearch Center of Clinical Epidemiology, Peking University Third HospitalDepartment of Orthopedics, Peking University Third HospitalDepartment of Orthopedics, Peking University Third HospitalDepartment of Orthopedics, Peking University Third HospitalInstitute of Sports Medicine, Peking University Third HospitalBeijing Haidian HospitalPeking University Third Hospital Yanqing HospitalPeking University Third Hospital Yanqing HospitalCenter of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third HospitalDrug Clinical Trial Center, Peking University Third HospitalDrug Clinical Trial Center, Peking University Third HospitalDepartment of Nursing, Peking University Third HospitalDepartment of Orthopedics, Peking University Third HospitalAbstract We aimed to investigate the preventive effect of vitamin D2 on COVID-19 and the improvement of symptoms after COVID-19 infection. The study recruited 228 health care workers who tested negative PCR or antigen for COVID-19. Subjects were randomly allocated to vitamin D2 or non-intervention at a ratio 1:1. Subjects recorded PCR or antigen tests and the symptoms of COVID-19 twice a week during the follow-up visit. The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines were measured. The rates of COVID-19 infection were 50.5% in the vitamin D2 group and 52.4% in the non-intervention group (P = 0.785). There was no difference in the COVID-19 symptoms between the two groups. The mean 25(OH)D level significantly increased from 14.1 to 31.1 ng/mL after administration (P < 0.001). The difference between the two groups was not significant for the concentrations of CRP, C1q and inflammatory cytokines on the thirtieth day of the trial. According to the second level of vitamin D, there was a 14.3% difference in positive infection rates between the vitamin D adequate (> 30 ng/mL) and deficient groups (< 20 ng/mL). Adequate vitamin D had a tendency to prevent COVID-19. Trial registration: ClinicalTrials.gov NCT05673980, dated: 12/2022.https://doi.org/10.1038/s41598-024-66267-8COVID-19Health care workersVitamin D2PreventionSeverity |
| spellingShingle | Huan Wang Liyuan Tao Liyan Cui Yahong Chen Dongyang Liu Lixiang Xue Yuping Yang Yang Lv Fuchun Zhang Tiancheng Wang Xiaoxiao Wang Wanqiong Yuan Hao Liu Jie Huang Yanfang Jiang Na Liu Lijuan Yang Yunjing Hu Yanfang Li Yuling Gao Haiyan Li Baohua Li Chunli Song Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19 Scientific Reports COVID-19 Health care workers Vitamin D2 Prevention Severity |
| title | Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19 |
| title_full | Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19 |
| title_fullStr | Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19 |
| title_full_unstemmed | Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19 |
| title_short | Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19 |
| title_sort | randomized trial of influence of vitamin d on the prevention and improvement of symptomatic covid 19 |
| topic | COVID-19 Health care workers Vitamin D2 Prevention Severity |
| url | https://doi.org/10.1038/s41598-024-66267-8 |
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