Promoting collagen synthesis: a viable strategy to combat skin ageing
Skin ageing is a complex physiological process primarily characterised by the deepening of wrinkles and the sagging of the skin. Collagen is essential for maintaining skin elasticity and firmness. As skin ages, it experiences structural and functional changes in collagen, including a decrease in col...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/14756366.2025.2488821 |
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| _version_ | 1850211791007645696 |
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| author | Shan Wang Feifan Li Xilong Feng Meiling Feng Xiaotian Niu Xiaoying Jiang Wenchao Chen Renren Bai |
| author_facet | Shan Wang Feifan Li Xilong Feng Meiling Feng Xiaotian Niu Xiaoying Jiang Wenchao Chen Renren Bai |
| author_sort | Shan Wang |
| collection | DOAJ |
| description | Skin ageing is a complex physiological process primarily characterised by the deepening of wrinkles and the sagging of the skin. Collagen is essential for maintaining skin elasticity and firmness. As skin ages, it experiences structural and functional changes in collagen, including a decrease in collagen synthesis and an increase in collagen hydrolysis. Thus, promoting collagen synthesis represents a practical strategy for mitigating skin ageing. This review systematically described the functions, classifications and biosynthesis process of collagen, as well as its role in skin ageing. Additionally, the major signalling pathways and targets associated with collagen synthesis were also discussed. More importantly, the review provided a detailed summary of natural products with collagen synthesis-promoting effects and highlighted small molecule compounds with potential anti-ageing activity, especially PPARδ agonists. The relevant content offers potential targets and lead compounds for the development of anti-skin ageing therapies. |
| format | Article |
| id | doaj-art-bb6ad510cedc4bd3a5be5074f7922e73 |
| institution | OA Journals |
| issn | 1475-6366 1475-6374 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj-art-bb6ad510cedc4bd3a5be5074f7922e732025-08-20T02:09:29ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742025-12-0140110.1080/14756366.2025.2488821Promoting collagen synthesis: a viable strategy to combat skin ageingShan Wang0Feifan Li1Xilong Feng2Meiling Feng3Xiaotian Niu4Xiaoying Jiang5Wenchao Chen6Renren Bai7School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, PR ChinaSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, PR ChinaSkin ageing is a complex physiological process primarily characterised by the deepening of wrinkles and the sagging of the skin. Collagen is essential for maintaining skin elasticity and firmness. As skin ages, it experiences structural and functional changes in collagen, including a decrease in collagen synthesis and an increase in collagen hydrolysis. Thus, promoting collagen synthesis represents a practical strategy for mitigating skin ageing. This review systematically described the functions, classifications and biosynthesis process of collagen, as well as its role in skin ageing. Additionally, the major signalling pathways and targets associated with collagen synthesis were also discussed. More importantly, the review provided a detailed summary of natural products with collagen synthesis-promoting effects and highlighted small molecule compounds with potential anti-ageing activity, especially PPARδ agonists. The relevant content offers potential targets and lead compounds for the development of anti-skin ageing therapies.https://www.tandfonline.com/doi/10.1080/14756366.2025.2488821Collagenskin ageingnatural productPPARδ agonistdrug discovery |
| spellingShingle | Shan Wang Feifan Li Xilong Feng Meiling Feng Xiaotian Niu Xiaoying Jiang Wenchao Chen Renren Bai Promoting collagen synthesis: a viable strategy to combat skin ageing Journal of Enzyme Inhibition and Medicinal Chemistry Collagen skin ageing natural product PPARδ agonist drug discovery |
| title | Promoting collagen synthesis: a viable strategy to combat skin ageing |
| title_full | Promoting collagen synthesis: a viable strategy to combat skin ageing |
| title_fullStr | Promoting collagen synthesis: a viable strategy to combat skin ageing |
| title_full_unstemmed | Promoting collagen synthesis: a viable strategy to combat skin ageing |
| title_short | Promoting collagen synthesis: a viable strategy to combat skin ageing |
| title_sort | promoting collagen synthesis a viable strategy to combat skin ageing |
| topic | Collagen skin ageing natural product PPARδ agonist drug discovery |
| url | https://www.tandfonline.com/doi/10.1080/14756366.2025.2488821 |
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