Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation
Neuroinflammation is considered a significant factor in triggering numerous neurodegenerative diseases. Hence, the development of effective anti-inflammatory drugs is of utmost urgency. In this study, three series of new isatin–chalcone hybrid derivatives were successfully designed and synthesized,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/7/1421 |
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| author | Rongrong Wang Zhili Zhang Wei Jiang Junyi Liu Chao Tian Meng Wang |
| author_facet | Rongrong Wang Zhili Zhang Wei Jiang Junyi Liu Chao Tian Meng Wang |
| author_sort | Rongrong Wang |
| collection | DOAJ |
| description | Neuroinflammation is considered a significant factor in triggering numerous neurodegenerative diseases. Hence, the development of effective anti-inflammatory drugs is of utmost urgency. In this study, three series of new isatin–chalcone hybrid derivatives were successfully designed and synthesized, and their anti-neuritis activities were explored using BV2 microglial cells. The results indicated that compound <b>4b</b> exhibited the most potent anti-inflammatory activity (IC<sub>50</sub> = 1.6 μM; TI = 21.6). After being treated with compound <b>4b</b>, the production of TNF-α and IL-6 decreased significantly (<i>p</i> < 0.0001). <i>In silico</i> molecular modeling studies on inflammation proteins suggested that compound <b>4b</b> might bind to TLR4/MD2 and p38. Predicted by the software Molinspiration, the Log <i>p</i> value and Log BB of compound <b>4b</b> were 3.36 and −0.32, respectively. |
| format | Article |
| id | doaj-art-bb69382f1d0b422fa785d0bdecd06644 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-bb69382f1d0b422fa785d0bdecd066442025-08-20T03:08:55ZengMDPI AGMolecules1420-30492025-03-01307142110.3390/molecules30071421Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity EvaluationRongrong Wang0Zhili Zhang1Wei Jiang2Junyi Liu3Chao Tian4Meng Wang5College of Pharmacy, Beihua University, Jilin 132013, ChinaDepartment of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaCollege of Pharmacy, Beihua University, Jilin 132013, ChinaDepartment of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaDepartment of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, ChinaCollege of Pharmacy, Beihua University, Jilin 132013, ChinaNeuroinflammation is considered a significant factor in triggering numerous neurodegenerative diseases. Hence, the development of effective anti-inflammatory drugs is of utmost urgency. In this study, three series of new isatin–chalcone hybrid derivatives were successfully designed and synthesized, and their anti-neuritis activities were explored using BV2 microglial cells. The results indicated that compound <b>4b</b> exhibited the most potent anti-inflammatory activity (IC<sub>50</sub> = 1.6 μM; TI = 21.6). After being treated with compound <b>4b</b>, the production of TNF-α and IL-6 decreased significantly (<i>p</i> < 0.0001). <i>In silico</i> molecular modeling studies on inflammation proteins suggested that compound <b>4b</b> might bind to TLR4/MD2 and p38. Predicted by the software Molinspiration, the Log <i>p</i> value and Log BB of compound <b>4b</b> were 3.36 and −0.32, respectively.https://www.mdpi.com/1420-3049/30/7/1421anti-neuroinflammatoryisatinnitric oxideTNF-αIL-6 |
| spellingShingle | Rongrong Wang Zhili Zhang Wei Jiang Junyi Liu Chao Tian Meng Wang Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation Molecules anti-neuroinflammatory isatin nitric oxide TNF-α IL-6 |
| title | Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation |
| title_full | Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation |
| title_fullStr | Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation |
| title_full_unstemmed | Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation |
| title_short | Novel Isatin–Chalcone Hybrid Molecules: Design, Synthesis and Anti-Neuroinflammatory Activity Evaluation |
| title_sort | novel isatin chalcone hybrid molecules design synthesis and anti neuroinflammatory activity evaluation |
| topic | anti-neuroinflammatory isatin nitric oxide TNF-α IL-6 |
| url | https://www.mdpi.com/1420-3049/30/7/1421 |
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