Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy

Development of a bacteria-nanosapper for the active delivery of ZIF-8 particles containing therapeutic genes for cancer immune therapy

Specific tumor-targeted gene delivery remains an unsolved therapeutic issue due to aberrant vascularization in tumor microenvironment (TME). Some bacteria exhibit spontaneous chemotaxis toward the anaerobic and immune-suppressive TME, which makes them ideal natural vehicles for cancer gene therapy....

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Bibliographic Details
Main Authors: Yiting Qiao, Miao Luo, Yufei Wang, Haoxiang Qi, Menglan Wang, Yunxin Pei, Mengqing Sun, Zhengguo Zhang, Jiacheng Huang, Pengyu Gong, Shusen Zheng, Jianxiang Chen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Bacteria-mediated cancer therapy
VNP20009
ZIF-8
Gene delivery
Tumor microenvironment
Tumor immune microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524003101
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