Association of childhood health with adulthood chronic kidney disease: results from the China Health and Retirement Longitudinal Study
ObjectiveAdverse Childhood Experiences have been well-documented as a risk factor for chronic kidney disease (CKD) in adulthood. However, the link between childhood health and adulthood CKD risk is still unclear. This study aimed to explore the connection between childhood health and the likelihood...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1538744/full |
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| author | Rong Lian Zheng-he Wang |
| author_facet | Rong Lian Zheng-he Wang |
| author_sort | Rong Lian |
| collection | DOAJ |
| description | ObjectiveAdverse Childhood Experiences have been well-documented as a risk factor for chronic kidney disease (CKD) in adulthood. However, the link between childhood health and adulthood CKD risk is still unclear. This study aimed to explore the connection between childhood health and the likelihood of developing CKD in adulthood.MethodsParticipants were drawn from the third wave of the China Health and Retirement Longitudinal Study (CHARLS). The CKD was identified based on the estimated Glomerular Filtration Rate (eGFR) and self-reported doctor-diagnosed kidney disease. Childhood health status was assessed through a standard questionnaire and categorized into excellent, fair, and poor groups.ResultsThe prevalence of CKD was 11.7% (1,480 out of 12,609). The eGFR levels in the self-reported Fair and Poor groups were significantly lower than those in the Excellent group (p < 0.05). Compared to the Excellent group, individuals in the Poor group reported a higher risk of CKD (OR = 1.38; 95% CI: 1.12–1.70; p = 0.002), even after adjusting for factors such as age, sex, smoking, alcohol consumption, physical activity, highest education level, use of Chinese traditional medicine, diabetes, hypertension, BMI, marital status, and annual household income (OR = 1.24; 95% CI: 1.01–1.54; p = 0.047).ConclusionThe CKD prevalence is notably high in the Chinese adults aged more than 45 years, and a history of poor health in childhood may significantly contribute to the risk of CKD in later life. |
| format | Article |
| id | doaj-art-bb6146c2b7eb4735a3c92c4bb57aff35 |
| institution | OA Journals |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-bb6146c2b7eb4735a3c92c4bb57aff352025-08-20T02:24:55ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-04-011310.3389/fpubh.2025.15387441538744Association of childhood health with adulthood chronic kidney disease: results from the China Health and Retirement Longitudinal StudyRong Lian0Zheng-he Wang1Department of Nephrology, Guangzhou First People’s Hospital, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, ChinaObjectiveAdverse Childhood Experiences have been well-documented as a risk factor for chronic kidney disease (CKD) in adulthood. However, the link between childhood health and adulthood CKD risk is still unclear. This study aimed to explore the connection between childhood health and the likelihood of developing CKD in adulthood.MethodsParticipants were drawn from the third wave of the China Health and Retirement Longitudinal Study (CHARLS). The CKD was identified based on the estimated Glomerular Filtration Rate (eGFR) and self-reported doctor-diagnosed kidney disease. Childhood health status was assessed through a standard questionnaire and categorized into excellent, fair, and poor groups.ResultsThe prevalence of CKD was 11.7% (1,480 out of 12,609). The eGFR levels in the self-reported Fair and Poor groups were significantly lower than those in the Excellent group (p < 0.05). Compared to the Excellent group, individuals in the Poor group reported a higher risk of CKD (OR = 1.38; 95% CI: 1.12–1.70; p = 0.002), even after adjusting for factors such as age, sex, smoking, alcohol consumption, physical activity, highest education level, use of Chinese traditional medicine, diabetes, hypertension, BMI, marital status, and annual household income (OR = 1.24; 95% CI: 1.01–1.54; p = 0.047).ConclusionThe CKD prevalence is notably high in the Chinese adults aged more than 45 years, and a history of poor health in childhood may significantly contribute to the risk of CKD in later life.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1538744/fullchildhood healthhealth statusGlomerular Filtration Ratechronic kidney diseasecommunity child healthnephrology |
| spellingShingle | Rong Lian Zheng-he Wang Association of childhood health with adulthood chronic kidney disease: results from the China Health and Retirement Longitudinal Study Frontiers in Public Health childhood health health status Glomerular Filtration Rate chronic kidney disease community child health nephrology |
| title | Association of childhood health with adulthood chronic kidney disease: results from the China Health and Retirement Longitudinal Study |
| title_full | Association of childhood health with adulthood chronic kidney disease: results from the China Health and Retirement Longitudinal Study |
| title_fullStr | Association of childhood health with adulthood chronic kidney disease: results from the China Health and Retirement Longitudinal Study |
| title_full_unstemmed | Association of childhood health with adulthood chronic kidney disease: results from the China Health and Retirement Longitudinal Study |
| title_short | Association of childhood health with adulthood chronic kidney disease: results from the China Health and Retirement Longitudinal Study |
| title_sort | association of childhood health with adulthood chronic kidney disease results from the china health and retirement longitudinal study |
| topic | childhood health health status Glomerular Filtration Rate chronic kidney disease community child health nephrology |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1538744/full |
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