Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis
Aim. The aim of the study is to determine the effectiveness of liver transplantation (LT) in the treatment of unresectable hepatocellular carcinoma (HCC) occurred in normal liver.Material and methods. 6 patients with unresectable HCC underwent orthotopic liver transplantation (OLT). The long-term...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2018-09-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/254 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860157140959232 |
|---|---|
| author | O. D. Olisov M. S. Novruzbekov I. E. Galankina L. N. Zimina V. A. Gulyaev L. V. Donova M. Sh. Khubutiya |
| author_facet | O. D. Olisov M. S. Novruzbekov I. E. Galankina L. N. Zimina V. A. Gulyaev L. V. Donova M. Sh. Khubutiya |
| author_sort | O. D. Olisov |
| collection | DOAJ |
| description | Aim. The aim of the study is to determine the effectiveness of liver transplantation (LT) in the treatment of unresectable hepatocellular carcinoma (HCC) occurred in normal liver.Material and methods. 6 patients with unresectable HCC underwent orthotopic liver transplantation (OLT). The long-term OLT results were compared with survival results of liver resection in patients with late stage HCC.Results. Hepatocellular carcinoma is one of the most common types of cancer, which occurs mainly in patients with liver cirrhosis and chronic viral hepatitis. Only about 10 % of HCC develops in non-cirrhotic liver among young and somatically healthy patients. 1-, 3-, 5-year recurrence-free and overall survival in LT group was significantly better than in the control group.Conclusion. LT is indicated for patients with unresectable HCC in non-cirrhotic liver and its extrahepatic localization. A large tumor size and macrovascular invasion should not be a contraindication for LT in such patients. |
| format | Article |
| id | doaj-art-bb606c77dbcb48de8bd88bd044cb73c3 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-bb606c77dbcb48de8bd88bd044cb73c32025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-09-01284768310.22416/1382-4376-2018-28-4-76-83254Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver CirrhosisO. D. Olisov0M. S. Novruzbekov1I. E. Galankina2L. N. Zimina3V. A. Gulyaev4L. V. Donova5M. Sh. Khubutiya6N.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineAim. The aim of the study is to determine the effectiveness of liver transplantation (LT) in the treatment of unresectable hepatocellular carcinoma (HCC) occurred in normal liver.Material and methods. 6 patients with unresectable HCC underwent orthotopic liver transplantation (OLT). The long-term OLT results were compared with survival results of liver resection in patients with late stage HCC.Results. Hepatocellular carcinoma is one of the most common types of cancer, which occurs mainly in patients with liver cirrhosis and chronic viral hepatitis. Only about 10 % of HCC develops in non-cirrhotic liver among young and somatically healthy patients. 1-, 3-, 5-year recurrence-free and overall survival in LT group was significantly better than in the control group.Conclusion. LT is indicated for patients with unresectable HCC in non-cirrhotic liver and its extrahepatic localization. A large tumor size and macrovascular invasion should not be a contraindication for LT in such patients.https://www.gastro-j.ru/jour/article/view/254hepatocellular carcinomaliver transplantationunresectable hepatocellular carcinoma in non-cirrhotic liveranabolic steroids |
| spellingShingle | O. D. Olisov M. S. Novruzbekov I. E. Galankina L. N. Zimina V. A. Gulyaev L. V. Donova M. Sh. Khubutiya Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis Российский журнал гастроэнтерологии, гепатологии, колопроктологии hepatocellular carcinoma liver transplantation unresectable hepatocellular carcinoma in non-cirrhotic liver anabolic steroids |
| title | Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis |
| title_full | Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis |
| title_fullStr | Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis |
| title_full_unstemmed | Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis |
| title_short | Liver Transplantation in the Treatment of Unresectable Hepatocellular Carcinoma in the Absence of Liver Cirrhosis |
| title_sort | liver transplantation in the treatment of unresectable hepatocellular carcinoma in the absence of liver cirrhosis |
| topic | hepatocellular carcinoma liver transplantation unresectable hepatocellular carcinoma in non-cirrhotic liver anabolic steroids |
| url | https://www.gastro-j.ru/jour/article/view/254 |
| work_keys_str_mv | AT odolisov livertransplantationinthetreatmentofunresectablehepatocellularcarcinomaintheabsenceoflivercirrhosis AT msnovruzbekov livertransplantationinthetreatmentofunresectablehepatocellularcarcinomaintheabsenceoflivercirrhosis AT iegalankina livertransplantationinthetreatmentofunresectablehepatocellularcarcinomaintheabsenceoflivercirrhosis AT lnzimina livertransplantationinthetreatmentofunresectablehepatocellularcarcinomaintheabsenceoflivercirrhosis AT vagulyaev livertransplantationinthetreatmentofunresectablehepatocellularcarcinomaintheabsenceoflivercirrhosis AT lvdonova livertransplantationinthetreatmentofunresectablehepatocellularcarcinomaintheabsenceoflivercirrhosis AT mshkhubutiya livertransplantationinthetreatmentofunresectablehepatocellularcarcinomaintheabsenceoflivercirrhosis |