Spectrophometric Determination of Nelfinavir Mesylate
Two new simple, sensitive, rapid and economical Spectrophotometric Methods (A and B) have been developed for the determination of Nelfinavir Mesylate in pharmaceutical bulk and tablet dosage form. The method A is based on the reaction of Nelfinavir with ferric chloride, potassium ferricyanide and hy...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2006/160909 |
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| author | K. Vanitha Prakash Jangala Venkateswara Rao |
| author_facet | K. Vanitha Prakash Jangala Venkateswara Rao |
| author_sort | K. Vanitha Prakash |
| collection | DOAJ |
| description | Two new simple, sensitive, rapid and economical Spectrophotometric Methods (A and B) have been developed for the determination of Nelfinavir Mesylate in pharmaceutical bulk and tablet dosage form. The method A is based on the reaction of Nelfinavir with ferric chloride, potassium ferricyanide and hydrochloric acid to form a bluish green colored chromogen. The Method B is based on the formation of blood red colored chromogen with Ferric chloride and 1,10-phenanthroline. The absorbances of the chromogen were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate. |
| format | Article |
| id | doaj-art-bb5f677294d74452a8499aa5c5d6411e |
| institution | DOAJ |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-bb5f677294d74452a8499aa5c5d6411e2025-08-20T03:23:07ZengWileyE-Journal of Chemistry0973-49452090-98102006-01-0132788210.1155/2006/160909Spectrophometric Determination of Nelfinavir MesylateK. Vanitha Prakash0Jangala Venkateswara Rao1Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road No. 3, Banjara Hills, Hyderabad-500 034, IndiaDepartment of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road No. 3, Banjara Hills, Hyderabad-500 034, IndiaTwo new simple, sensitive, rapid and economical Spectrophotometric Methods (A and B) have been developed for the determination of Nelfinavir Mesylate in pharmaceutical bulk and tablet dosage form. The method A is based on the reaction of Nelfinavir with ferric chloride, potassium ferricyanide and hydrochloric acid to form a bluish green colored chromogen. The Method B is based on the formation of blood red colored chromogen with Ferric chloride and 1,10-phenanthroline. The absorbances of the chromogen were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.http://dx.doi.org/10.1155/2006/160909 |
| spellingShingle | K. Vanitha Prakash Jangala Venkateswara Rao Spectrophometric Determination of Nelfinavir Mesylate E-Journal of Chemistry |
| title | Spectrophometric Determination of Nelfinavir Mesylate |
| title_full | Spectrophometric Determination of Nelfinavir Mesylate |
| title_fullStr | Spectrophometric Determination of Nelfinavir Mesylate |
| title_full_unstemmed | Spectrophometric Determination of Nelfinavir Mesylate |
| title_short | Spectrophometric Determination of Nelfinavir Mesylate |
| title_sort | spectrophometric determination of nelfinavir mesylate |
| url | http://dx.doi.org/10.1155/2006/160909 |
| work_keys_str_mv | AT kvanithaprakash spectrophometricdeterminationofnelfinavirmesylate AT jangalavenkateswararao spectrophometricdeterminationofnelfinavirmesylate |