A double-edged sword role of IFN-γ-producing iNKT cells in sepsis: Persistent suppression of Treg cell formation in an Nr4a1-dependent manner

A double-edged sword role of IFN-γ-producing iNKT cells in sepsis: Persistent suppression of Treg cell formation in an Nr4a1-dependent manner

Summary: Sepsis, a leading cause of mortality in intensive care units worldwide, lacks effective treatments for advanced-stage sepsis. Therefore, understanding the underlying mechanisms of this disease is crucial. This study reveals that invariant natural killer T (iNKT) cells have an opposing role...

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Bibliographic Details
Main Authors: Yingyu Qin, Yilin Qian, Shengqiu Liu, Rong Chen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Biological sciences
Immune response
Immune system
Immunology
Natural sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224026890
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