Lipopolysaccharide Induces Mitochondrial Fragmentation and Energetic Shift in Reactive Microglia: Evidence for a Cell-Autonomous Program of Metabolic Plasticity

Lipopolysaccharide Induces Mitochondrial Fragmentation and Energetic Shift in Reactive Microglia: Evidence for a Cell-Autonomous Program of Metabolic Plasticity

Microglia, the resident immune cells of the central nervous system (CNS), play essential roles in maintaining brain homeostasis. While transient activation is protective, chronic microglial reactivity contributes to neuroinflammatory damage and neurodegeneration. The mitochondrial mechanisms underly...

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Bibliographic Details
Main Authors: Marcelle Pereira dos Santos, Vitor Emanuel Leocadio, Lívia de Sá Hayashide, Mariana Marques, Clara Fernandes Carvalho, Antonio Galina, Luan Pereira Diniz
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Toxins
Subjects:
microglia
BV-2 Cell Line
LPS
neuroinflammation
mitochondrial fragmentation
energetic failure
Online Access:https://www.mdpi.com/2072-6651/17/6/293
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