CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis.
<h4>Objective</h4>CD133 has recently been reported as a marker of cancer stem-like cells in colorectal cancer (CRC). However, its predictive value in CRC still remains controversial. In this study, we aimed to evaluate the association between the expression of CD133 and clinicopathologic...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0056380 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849426945977090048 |
|---|---|
| author | Shicai Chen Xinming Song Zhihui Chen Xinxin Li Mingzhe Li Haiying Liu Jianchang Li |
| author_facet | Shicai Chen Xinming Song Zhihui Chen Xinxin Li Mingzhe Li Haiying Liu Jianchang Li |
| author_sort | Shicai Chen |
| collection | DOAJ |
| description | <h4>Objective</h4>CD133 has recently been reported as a marker of cancer stem-like cells in colorectal cancer (CRC). However, its predictive value in CRC still remains controversial. In this study, we aimed to evaluate the association between the expression of CD133 and clinicopathological features and the outcome of CRC patients by performing a meta-analysis.<h4>Methods</h4>A comprehensive literature search for relevant studies published up to December 2012 was performed using PubMed, MEDLINE and ISI Web of Science. Only articles in which CD133 antigen was detected in situ localisation by immunohistochemical staining were included. This meta-analysis was done using RevMan 4.2 software.<h4>Results</h4>We found that a total of 15 studies involving 810 CD133-high and 1487 CD133-low patients met the inclusion criteria for the analysis of 5-year overall survival (OS) rate. In a random-effects model, the results showed that CD133-high expression in colorectal cancer was an independent prognostic marker correlating with both OS rate (RR = 0.67, 95%CI 0.54-0.82, P<0.01) and disease free survival (DFS) rate (RR = 0.71, 95%CI 0.52-0.96, P = 0.03). CD133-high expression was also associated with more T3,4 tumor invasion, N positive and vascular invasion cases, corresponding to a risk difference of 1.12 (95%CI 1.01-1.23, P = 0.03), 1.31 (95%CI 1.06-1.63, P = 0.01) and 1.24 (95%CI 1.08-1.41, P<0.01), respectively. However, when types of histology, lymphatic invasion and distant metastasis were considered, CD133 overexpression was not significantly related with these clinicopathological parameters.<h4>Conclusion</h4>Our meta-analysis results suggest that CD133 is an efficient prognostic factor in CRC. Higher CD133 expression is significantly associated with poorer clinical outcome and some clinicopathological factors such as T category, N category and vascular invasion in CRC patients. |
| format | Article |
| id | doaj-art-bb48e07693d64348b3a4f60aec6ddc95 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-bb48e07693d64348b3a4f60aec6ddc952025-08-20T03:29:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5638010.1371/journal.pone.0056380CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis.Shicai ChenXinming SongZhihui ChenXinxin LiMingzhe LiHaiying LiuJianchang Li<h4>Objective</h4>CD133 has recently been reported as a marker of cancer stem-like cells in colorectal cancer (CRC). However, its predictive value in CRC still remains controversial. In this study, we aimed to evaluate the association between the expression of CD133 and clinicopathological features and the outcome of CRC patients by performing a meta-analysis.<h4>Methods</h4>A comprehensive literature search for relevant studies published up to December 2012 was performed using PubMed, MEDLINE and ISI Web of Science. Only articles in which CD133 antigen was detected in situ localisation by immunohistochemical staining were included. This meta-analysis was done using RevMan 4.2 software.<h4>Results</h4>We found that a total of 15 studies involving 810 CD133-high and 1487 CD133-low patients met the inclusion criteria for the analysis of 5-year overall survival (OS) rate. In a random-effects model, the results showed that CD133-high expression in colorectal cancer was an independent prognostic marker correlating with both OS rate (RR = 0.67, 95%CI 0.54-0.82, P<0.01) and disease free survival (DFS) rate (RR = 0.71, 95%CI 0.52-0.96, P = 0.03). CD133-high expression was also associated with more T3,4 tumor invasion, N positive and vascular invasion cases, corresponding to a risk difference of 1.12 (95%CI 1.01-1.23, P = 0.03), 1.31 (95%CI 1.06-1.63, P = 0.01) and 1.24 (95%CI 1.08-1.41, P<0.01), respectively. However, when types of histology, lymphatic invasion and distant metastasis were considered, CD133 overexpression was not significantly related with these clinicopathological parameters.<h4>Conclusion</h4>Our meta-analysis results suggest that CD133 is an efficient prognostic factor in CRC. Higher CD133 expression is significantly associated with poorer clinical outcome and some clinicopathological factors such as T category, N category and vascular invasion in CRC patients.https://doi.org/10.1371/journal.pone.0056380 |
| spellingShingle | Shicai Chen Xinming Song Zhihui Chen Xinxin Li Mingzhe Li Haiying Liu Jianchang Li CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis. PLoS ONE |
| title | CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis. |
| title_full | CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis. |
| title_fullStr | CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis. |
| title_full_unstemmed | CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis. |
| title_short | CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis. |
| title_sort | cd133 expression and the prognosis of colorectal cancer a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0056380 |
| work_keys_str_mv | AT shicaichen cd133expressionandtheprognosisofcolorectalcancerasystematicreviewandmetaanalysis AT xinmingsong cd133expressionandtheprognosisofcolorectalcancerasystematicreviewandmetaanalysis AT zhihuichen cd133expressionandtheprognosisofcolorectalcancerasystematicreviewandmetaanalysis AT xinxinli cd133expressionandtheprognosisofcolorectalcancerasystematicreviewandmetaanalysis AT mingzheli cd133expressionandtheprognosisofcolorectalcancerasystematicreviewandmetaanalysis AT haiyingliu cd133expressionandtheprognosisofcolorectalcancerasystematicreviewandmetaanalysis AT jianchangli cd133expressionandtheprognosisofcolorectalcancerasystematicreviewandmetaanalysis |