A Randomized Controlled Study Comparing Albumin-Enriched Platelet-Rich Fibrin and Conventional Platelet-Rich Fibrin for the Treatment of Intrabony Defects
Background: The treatment of intrabony defects (IBDs) is a significant challenge in periodontal therapy, with regenerative approaches like platelet concentrates showing promising outcomes. Materials and Methods: A randomized controlled study was conducted on 20 IBDs from patients who met the inclusi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_190_25 |
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| author | Sharmila Kumari Amit Kumar Sharma Mysore Kantharaja Setty Sunil Sri Krishna Koppula Sunil Sharma |
| author_facet | Sharmila Kumari Amit Kumar Sharma Mysore Kantharaja Setty Sunil Sri Krishna Koppula Sunil Sharma |
| author_sort | Sharmila Kumari |
| collection | DOAJ |
| description | Background:
The treatment of intrabony defects (IBDs) is a significant challenge in periodontal therapy, with regenerative approaches like platelet concentrates showing promising outcomes.
Materials and Methods:
A randomized controlled study was conducted on 20 IBDs from patients who met the inclusion criteria. After Phase I therapy, the defects were randomly assigned to two groups: Group I: Treated with open-flap debridement (OFD) and albumin platelet-rich fibrin (Alb-PRF), Group II: Treated with OFD and PRF. Clinical parameters, including plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL), were recorded at baseline and one month postoperatively. Alb-PRF was prepared by centrifuging blood samples at 2,700 rpm for 12 min, collecting the liquid-phase PRF, heating the platelet–poor plasma at 75°C, cooling it, and mixing it with the buffy coat.
Results:
Both groups showed significant improvement in clinical parameters after one month. In Group I, the mean PPD reduction was 3.2 mm, and CAL gain was 2.8 mm, while in Group II, PPD reduction was 2.9 mm, and CAL gain was 2.5 mm. The reduction in BOP was 50% in Group I and 45% in Group II. PI improvement was similar across groups. Alb-PRF demonstrated a marginally better performance in all clinical parameters compared to PRF alone.
Conclusion:
Alb-PRF, as an adjunct to OFD, showed better outcomes in reducing PPD and gaining CAL compared to PRF. The results suggest that Alb-PRF may provide a superior regenerative effect in managing IBDs over a short-term period. |
| format | Article |
| id | doaj-art-bb45b109431e4718a785cc3a3ee4ba6e |
| institution | DOAJ |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-bb45b109431e4718a785cc3a3ee4ba6e2025-08-20T03:15:19ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1619S162110.4103/jpbs.jpbs_190_25A Randomized Controlled Study Comparing Albumin-Enriched Platelet-Rich Fibrin and Conventional Platelet-Rich Fibrin for the Treatment of Intrabony DefectsSharmila KumariAmit Kumar SharmaMysore Kantharaja Setty SunilSri Krishna KoppulaSunil SharmaBackground: The treatment of intrabony defects (IBDs) is a significant challenge in periodontal therapy, with regenerative approaches like platelet concentrates showing promising outcomes. Materials and Methods: A randomized controlled study was conducted on 20 IBDs from patients who met the inclusion criteria. After Phase I therapy, the defects were randomly assigned to two groups: Group I: Treated with open-flap debridement (OFD) and albumin platelet-rich fibrin (Alb-PRF), Group II: Treated with OFD and PRF. Clinical parameters, including plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL), were recorded at baseline and one month postoperatively. Alb-PRF was prepared by centrifuging blood samples at 2,700 rpm for 12 min, collecting the liquid-phase PRF, heating the platelet–poor plasma at 75°C, cooling it, and mixing it with the buffy coat. Results: Both groups showed significant improvement in clinical parameters after one month. In Group I, the mean PPD reduction was 3.2 mm, and CAL gain was 2.8 mm, while in Group II, PPD reduction was 2.9 mm, and CAL gain was 2.5 mm. The reduction in BOP was 50% in Group I and 45% in Group II. PI improvement was similar across groups. Alb-PRF demonstrated a marginally better performance in all clinical parameters compared to PRF alone. Conclusion: Alb-PRF, as an adjunct to OFD, showed better outcomes in reducing PPD and gaining CAL compared to PRF. The results suggest that Alb-PRF may provide a superior regenerative effect in managing IBDs over a short-term period.https://journals.lww.com/10.4103/jpbs.jpbs_190_25albumin platelet-rich fibrinhydroxyapatiteintrabony defectsperiodontal treatmentplatelet-rich fibrinregenerative therapy |
| spellingShingle | Sharmila Kumari Amit Kumar Sharma Mysore Kantharaja Setty Sunil Sri Krishna Koppula Sunil Sharma A Randomized Controlled Study Comparing Albumin-Enriched Platelet-Rich Fibrin and Conventional Platelet-Rich Fibrin for the Treatment of Intrabony Defects Journal of Pharmacy and Bioallied Sciences albumin platelet-rich fibrin hydroxyapatite intrabony defects periodontal treatment platelet-rich fibrin regenerative therapy |
| title | A Randomized Controlled Study Comparing Albumin-Enriched Platelet-Rich Fibrin and Conventional Platelet-Rich Fibrin for the Treatment of Intrabony Defects |
| title_full | A Randomized Controlled Study Comparing Albumin-Enriched Platelet-Rich Fibrin and Conventional Platelet-Rich Fibrin for the Treatment of Intrabony Defects |
| title_fullStr | A Randomized Controlled Study Comparing Albumin-Enriched Platelet-Rich Fibrin and Conventional Platelet-Rich Fibrin for the Treatment of Intrabony Defects |
| title_full_unstemmed | A Randomized Controlled Study Comparing Albumin-Enriched Platelet-Rich Fibrin and Conventional Platelet-Rich Fibrin for the Treatment of Intrabony Defects |
| title_short | A Randomized Controlled Study Comparing Albumin-Enriched Platelet-Rich Fibrin and Conventional Platelet-Rich Fibrin for the Treatment of Intrabony Defects |
| title_sort | randomized controlled study comparing albumin enriched platelet rich fibrin and conventional platelet rich fibrin for the treatment of intrabony defects |
| topic | albumin platelet-rich fibrin hydroxyapatite intrabony defects periodontal treatment platelet-rich fibrin regenerative therapy |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_190_25 |
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