Bifidobacterium spp. and their metabolite lactate protect against acute pancreatitis via inhibition of pancreatic and systemic inflammatory responses

Bifidobacterium spp. and their metabolite lactate protect against acute pancreatitis via inhibition of pancreatic and systemic inflammatory responses

Severe acute pancreatitis (SAP) is a critical illness characterized by a severe systemic inflammatory response resulting in persistent multiple organ failure and sepsis. The intestinal microbiome is increasingly appreciated to play a crucial role in modulation of AP disease outcome, but limited info...

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Main Authors: Han Li, Jinyan Xie, Xiuliu Guo, Guilian Yang, Bin Cai, Jingtianyi Liu, Mengjia Yue, Yixin Tang, Gan Wang, Shuxian Chen, Jialin Guo, Xuchen Qi, Donghai Wang, Huijun Zheng, Wei Liu, Hong Yu, Chunfeng Wang, Shu Jeffrey Zhu, Feng Guo
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Bifidobacterium
microbial metabolite
lactate
macrophages
pancreatic and systemic inflammation
immunomodulation
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2127456
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